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Brief Report

TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients

1
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain
2
Servicio de Laboratorio Clínico, Hospital de Antequera, 29200 Málaga, Spain
3
Servicio de Digestivo, Hospital Virgen de la Salud, 45004 Toledo, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this study.
Academic Editor: Raymond Noordam
J. Clin. Med. 2021, 10(3), 483; https://doi.org/10.3390/jcm10030483
Received: 20 December 2020 / Revised: 23 January 2021 / Accepted: 25 January 2021 / Published: 28 January 2021
Background: TRPM5 (transient receptor potential cation channel subfamily M member 5) rs886277 polymorphism has been related to liver cirrhosis from different etiologies. The present study investigates the association of TRPM5 rs886277 polymorphism with liver fibrosis progression and cirrhosis development in chronic hepatitis C (CHC) patients. Methods: We conducted a retrospective study of 208 non-cirrhotic patients with CHC, who had at least two liver stiffness measurements (LSM) with a separation of 12 months (baseline LSM (LSM1) and the last LSM (LSM2)). Two outcome variables were considered: (1) LSM2/LSM1 ratio; (2) cirrhosis progression (F4; LSM ≥ 12.5 kPa). DNA genotyping was done at the CeGen using a MassARRAY platform. Results: The follow-up time was similar irrespective of the rs886277 genotype (46.4 months in TT genotype, 46.4 months in CT genotype, and 49.2 months in CC genotype; p = 0.649). The highest LSM increases were found in patients with CC genotype compared with TT and CT genotypes (p = 0.044 and p = 0.038, respectively). The cirrhosis progression was higher in patients with CC genotype than TT genotype (p = 0.033). Thus, the rs886277 C allele was associated with higher cirrhosis progression (adjusted odds ratio (aOR) = 2.64; p = 0.014). Moreover, rs886277 CC genotype was also related to higher values of LSM2/LSM1 ratio (adjusted arithmetic mean ratio a(AMR) = 1.31; p = 0.001) and cirrhosis progression (aOR = 4.33; p = 0.027). Conclusions: TRPM5 rs886277 polymorphism was associated with liver fibrosis progression and cirrhosis development among hepatitis C virus (HCV)-infected patients. Specifically, the rs886277 C allele and CC genotype were risk factors for advancing liver fibrosis and cirrhosis compared to the rs886277 T allele and CT/TT genotype, respectively. View Full-Text
Keywords: chronic hepatitis C; hepatic fibrosis; cirrhosis; liver stiffness; TRPM5; SNPs chronic hepatitis C; hepatic fibrosis; cirrhosis; liver stiffness; TRPM5; SNPs
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MDPI and ACS Style

Resino, S.; Fernández-Rodríguez, A.; Pineda-Tenor, D.; Gómez-Moreno, A.Z.; Sánchez-Ruano, J.J.; Artaza-Varasa, T.; Muñoz-Gómez, M.J.; Virseda-Berdices, A.; Martín-Vicente, M.; Martínez, I.; Jiménez-Sousa, M.A. TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients. J. Clin. Med. 2021, 10, 483. https://doi.org/10.3390/jcm10030483

AMA Style

Resino S, Fernández-Rodríguez A, Pineda-Tenor D, Gómez-Moreno AZ, Sánchez-Ruano JJ, Artaza-Varasa T, Muñoz-Gómez MJ, Virseda-Berdices A, Martín-Vicente M, Martínez I, Jiménez-Sousa MA. TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients. Journal of Clinical Medicine. 2021; 10(3):483. https://doi.org/10.3390/jcm10030483

Chicago/Turabian Style

Resino, Salvador, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, Ana Z. Gómez-Moreno, Juan J. Sánchez-Ruano, Tomas Artaza-Varasa, María J. Muñoz-Gómez, Ana Virseda-Berdices, María Martín-Vicente, Isidoro Martínez, and María A. Jiménez-Sousa 2021. "TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients" Journal of Clinical Medicine 10, no. 3: 483. https://doi.org/10.3390/jcm10030483

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