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Article

Myocardial Injury as a Prognostic Factor in Mid- and Long-Term Follow-Up of COVID-19 Survivors

1
Cardiology Department, Hospital del Mar, Passeig Marítim de la Barceloneta 25-29, 08003 Barcelona, Spain
2
Medicine Department, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain
3
Cardiology Department, Joan XXIII University Hospital of Tarragona, 430005 Tarragona, Spain
4
Institut Investigació Sanitària Pere i Virgili (IISPV), 43007 Tarragona, Spain
5
Medicine Department, Rovira i Virgili University, 43002 Tarragona, Spain
6
Medicine Department, Pompeu Fabra University, 08005 Barcelona, Spain
7
Scientific Coordination Facility, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain
8
Heart Disease Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
9
CIBER Group in Epidemiology and Public Heath (CIBERCV), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain
10
REGICOR (Registre Gironí del Cor) Study Group, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
*
Author to whom correspondence should be addressed.
These authors equally contributed to the present manuscript.
Academic Editor: Patrick De Boever
J. Clin. Med. 2021, 10(24), 5900; https://doi.org/10.3390/jcm10245900
Received: 26 November 2021 / Revised: 13 December 2021 / Accepted: 14 December 2021 / Published: 16 December 2021
Myocardial injury, which is present in >20% of patients hospitalized for COVID-19, is associated with increased short-term mortality, but little is known about its mid- and long-term consequences. We evaluated the association between myocardial injury with one-year mortality and readmission in 172 COVID-19 patients discharged alive. Patients were grouped according to the presence or absence of myocardial injury (defined by hs-cTn levels) on admission and matched by age and sex. We report mortality and hospital readmission at one year after admission in all patients and echocardiographic, laboratory and clinical data at six months in a subset of 86 patients. Patients with myocardial injury had a higher prevalence of hypertension (73.3% vs. 50.0%, p = 0.003), chronic kidney disease (10.5% vs. 2.35%, p = 0.06) and chronic heart failure (9.3% vs. 1.16%, p = 0.03) on admission. They also had higher mortality or hospital readmissions at one year (11.6% vs. 1.16%, p = 0.01). Additionally, echocardiograms showed thicker walls in these patients (10 mm vs. 8 mm, p = 0.002) but without functional disorder. Myocardial injury in COVID-19 survivors is associated with poor clinical prognosis at one year, independent of age and sex, but not with echocardiographic functional abnormalities at six months. View Full-Text
Keywords: myocardial injury; COVID-19; long-term; prognosis; mortality; readmission myocardial injury; COVID-19; long-term; prognosis; mortality; readmission
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MDPI and ACS Style

Izquierdo, A.; Mojón, D.; Bardají, A.; Carrasquer, A.; Calvo-Fernández, A.; Carreras-Mora, J.; Giralt, T.; Pérez-Fernández, S.; Farré, N.; Soler, C.; Solà-Richarte, C.; Cabero, P.; Vaquerizo, B.; Marrugat, J.; Ribas, N. Myocardial Injury as a Prognostic Factor in Mid- and Long-Term Follow-Up of COVID-19 Survivors. J. Clin. Med. 2021, 10, 5900. https://doi.org/10.3390/jcm10245900

AMA Style

Izquierdo A, Mojón D, Bardají A, Carrasquer A, Calvo-Fernández A, Carreras-Mora J, Giralt T, Pérez-Fernández S, Farré N, Soler C, Solà-Richarte C, Cabero P, Vaquerizo B, Marrugat J, Ribas N. Myocardial Injury as a Prognostic Factor in Mid- and Long-Term Follow-Up of COVID-19 Survivors. Journal of Clinical Medicine. 2021; 10(24):5900. https://doi.org/10.3390/jcm10245900

Chicago/Turabian Style

Izquierdo, Andrea, Diana Mojón, Alfredo Bardají, Anna Carrasquer, Alicia Calvo-Fernández, José Carreras-Mora, Teresa Giralt, Sílvia Pérez-Fernández, Núria Farré, Cristina Soler, Clàudia Solà-Richarte, Paula Cabero, Beatriz Vaquerizo, Jaume Marrugat, and Núria Ribas. 2021. "Myocardial Injury as a Prognostic Factor in Mid- and Long-Term Follow-Up of COVID-19 Survivors" Journal of Clinical Medicine 10, no. 24: 5900. https://doi.org/10.3390/jcm10245900

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