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Open AccessArticle

Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain

1
Department of Internal Medicine, Hospital General de Tomelloso, 13700 Ciudad Real, Spain
2
Research Unit, Hospital General La Mancha Centro, Alcázar de San Juan, 13600 Ciudad Real, Spain
3
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
4
Department of Gastroenterology, Hospital General de Tomelloso, 13700 Ciudad Real, Spain
5
Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 318; https://doi.org/10.3390/jcm10020318
Received: 5 December 2020 / Revised: 13 January 2021 / Accepted: 14 January 2021 / Published: 16 January 2021
Background: Risk factors for in-hospital mortality from severe coronavirus disease 2019 (COVID-19) infection have been identified in studies mainly carried out in urban-based teaching hospitals. However, there is little data for rural populations attending community hospitals during the first wave of the pandemic. Methods: A retrospective, single-center cohort study was undertaken among inpatients at a rural community hospital in Spain. Electronic medical records of the 444 patients (56.5% males) admitted due to severe SARS-CoV-2 infection during 26 February 2020–31 May 2020 were reviewed. Results: Mean age was 71.2 ± 14.6 years (rank 22–98), with 69.8% over 65. At least one comorbidity was present in 410 patients (92.3%), with chronic obstructive pulmonary disease (COPD) present in 21.7%. Overall in-hospital mortality was 32%. Multivariate analysis of factors associated with death identified patients’ age (with a cumulative effect per decade), COPD as a comorbidity, and respiratory insufficiency at the point of admission. No additional comorbid conditions proved significant. Among analytical values, increased serum creatinine, LDH > 500 mg/dL, thrombocytopenia (<150 × 109/per L), and lymphopenia (<1000 cells/µL) were all independently associated with mortality during admission. Conclusions: Age remained the major determinant for COVID-19-caused mortality; COPD was the only comorbidity independently associated with in-hospital death, together with respiratory insufficiency and analytical markers at admission. View Full-Text
Keywords: risk factors; predictors; mortality; COVID-19; Spain risk factors; predictors; mortality; COVID-19; Spain
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MDPI and ACS Style

Maestre-Muñiz, M.M.; Arias, Á.; Arias-González, L.; Angulo-Lara, B.; Lucendo, A.J. Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain. J. Clin. Med. 2021, 10, 318. https://doi.org/10.3390/jcm10020318

AMA Style

Maestre-Muñiz MM, Arias Á, Arias-González L, Angulo-Lara B, Lucendo AJ. Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain. Journal of Clinical Medicine. 2021; 10(2):318. https://doi.org/10.3390/jcm10020318

Chicago/Turabian Style

Maestre-Muñiz, Modesto M.; Arias, Ángel; Arias-González, Laura; Angulo-Lara, Basilio; Lucendo, Alfredo J. 2021. "Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain" J. Clin. Med. 10, no. 2: 318. https://doi.org/10.3390/jcm10020318

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