Next Article in Journal
Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain
Previous Article in Journal
Efficiency of Teeth Bleaching after Regenerative Endodontic Treatment: A Systematic Review
Review

Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries

1
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy
2
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, 10126 Turin, Italy
3
Ophthalmology Veterinary Practice, c.so Galileo Ferraris 121, 10126 Turin, Italy
4
Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy
5
Laboratory of Stem Cell Research and Application, and Stem Cell Institute, VNUHCM University of Science, Ho Chi Minh City 08000, Vietnam
*
Authors to whom correspondence should be addressed.
Equal contribution.
Equal supervision.
J. Clin. Med. 2021, 10(2), 317; https://doi.org/10.3390/jcm10020317
Received: 13 December 2020 / Revised: 12 January 2021 / Accepted: 14 January 2021 / Published: 16 January 2021
(This article belongs to the Section Ophthalmology)
Ocular chemical and thermal burns are frequent causes of hospitalization and require immediate interventions and care. Various surgical and pharmacological treatment strategies are employed according to damage severity. Controlling inflammation and neovascularization while promoting normal ocular surface anatomy and function restoration is the principal aim. In the most severe cases, when epithelial healing is severely affected, reconstruction of the ocular surface may be a valid option, which, however, requires expertise, adequate instruments, and qualified donors. Numerous endogenous and exogenous strategies have been considered for corneal repair. Among these, stem cells and their derivatives have offered numerous attractive possibilities in finding an effective way in stimulating corneal regeneration. Limbal epithelial stem cells and mesenchymal cells from the ocular tissue as well as from various sources have demonstrated their effectiveness in dampening neovascularization, scarring, and inflammation, while promoting epithelialization of the injured cornea. Moreover, a plethora of cytokines and growth factors, and extracellular vesicles, which constitute the secretome of these cells, work in concert to enhance wound healing. In this review, we provide an update on the recent potential therapeutic avenues and clinical applications of stem cells and their products in corneal regeneration after burn injury, as well as current imaging strategies for monitoring therapeutic efficacy and damage resolution. View Full-Text
Keywords: cornea; stem cells; extracellular vesicles; burn injury; wound healing; imaging cornea; stem cells; extracellular vesicles; burn injury; wound healing; imaging
Show Figures

Figure 1

MDPI and ACS Style

Saccu, G.; Menchise, V.; Giordano, C.; Delli Castelli, D.; Dastrù, W.; Pellicano, R.; Tolosano, E.; Van Pham, P.; Altruda, F.; Fagoonee, S. Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries. J. Clin. Med. 2021, 10, 317. https://doi.org/10.3390/jcm10020317

AMA Style

Saccu G, Menchise V, Giordano C, Delli Castelli D, Dastrù W, Pellicano R, Tolosano E, Van Pham P, Altruda F, Fagoonee S. Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries. Journal of Clinical Medicine. 2021; 10(2):317. https://doi.org/10.3390/jcm10020317

Chicago/Turabian Style

Saccu, Gabriele, Valeria Menchise, Cristina Giordano, Daniela Delli Castelli, Walter Dastrù, Rinaldo Pellicano, Emanuela Tolosano, Phuc Van Pham, Fiorella Altruda, and Sharmila Fagoonee. 2021. "Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries" Journal of Clinical Medicine 10, no. 2: 317. https://doi.org/10.3390/jcm10020317

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop