Next Article in Journal
Early vs. Late Tracheostomy in Patients with Traumatic Brain Injury: Systematic Review and Meta-Analysis
Previous Article in Journal
Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Systematic Review and Meta-Analysis
 
 
Review

Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis

1
Department of Internal Medicine, University of Hawaii Internal Medicine Residency Program, Honolulu, HI 96813, USA
2
Department of Cardiovascular Medicine, University of California-Riverside, Riverside, CA 92521, USA
3
The Queen’s Medical Center, Queen’s Heart Institute, Honolulu, HI 96813, USA
4
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Zielke
J. Clin. Med. 2021, 10(15), 3318; https://doi.org/10.3390/jcm10153318
Received: 7 July 2021 / Revised: 23 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Section Endocrinology & Metabolism)
Subclinical hypothyroidism (SCH) has been found to be associated with an increased risk of cardiovascular diseases. However, there is no clear consensus on the relationship between SCH and hypertension (HTN). We sought to investigate the association between SCH and incident HTN in women. MEDLINE and EMBASE databases were searched for studies that reported the incidence of HTN in females with SCH versus without SCH. Pooled odds ratio (OR) and 95% confidence interval (CI) of the outcome were obtained using a random-effects model. Studies were also divided into the middle-aged (mean age < 65) and the older (mean age ≥ 65) subgroups, and a subgroup analysis was performed to examine the potential age-effect on the association between SCH and HTN. Nine studies with a total of 21,972 subjects met the inclusion criteria. SCH was found to be positively associated with HTN (OR = 1.32, 95% CI = 1.02–1.71). Such association varied depending on the age of women. In the middle-aged subgroup, SCH was more positively associated with HTN (OR = 1.64, 95% CI = 1.18–2.27), while there was no significant association in the older subgroup (OR = 0.97, 95% CI = 0.80–1.16). Our study showed that the middle-aged females with SCH had an increased risk of HTN, while there was no significant association in the older females with SCH. View Full-Text
Keywords: subclinical hypothyroidism; thyroid; hypertension; blood pressure; females; meta-analysis subclinical hypothyroidism; thyroid; hypertension; blood pressure; females; meta-analysis
Show Figures

Figure 1

MDPI and ACS Style

Kim, J.; Prasitlumkum, N.; Randhawa, S.; Banerjee, D. Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis. J. Clin. Med. 2021, 10, 3318. https://doi.org/10.3390/jcm10153318

AMA Style

Kim J, Prasitlumkum N, Randhawa S, Banerjee D. Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2021; 10(15):3318. https://doi.org/10.3390/jcm10153318

Chicago/Turabian Style

Kim, Jean, Narut Prasitlumkum, Sandeep Randhawa, and Dipanjan Banerjee. 2021. "Association between Subclinical Hypothyroidism and Incident Hypertension in Women: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 10, no. 15: 3318. https://doi.org/10.3390/jcm10153318

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop