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Chemotherapy for Biliary Tract Cancer in 2021

Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo 135-8550, Japan
Author to whom correspondence should be addressed.
Academic Editor: Stanley W. Ashley
J. Clin. Med. 2021, 10(14), 3108;
Received: 18 June 2021 / Revised: 12 July 2021 / Accepted: 13 July 2021 / Published: 14 July 2021
Biliary tract cancer refers to a group of malignancies including cholangiocarcinoma, gallbladder cancer, and ampullary cancer. While surgical resection is considered the only curative treatment, postoperative recurrence can sometimes occur. Adjuvant chemotherapy is used to prolong prognosis in some cases. Many unresectable cases are also treated with chemotherapy. Therefore, systemic chemotherapy is widely introduced for the treatment of biliary tract cancer. Evidence on chemotherapy for biliary tract cancer is recently on the increase. Combination chemotherapy with gemcitabine and cisplatin is currently the standard of care for first-line chemotherapy in advanced cases. Recently, FOLFOX also demonstrated efficacy as a second-line treatment. In addition, efficacies of isocitrate dehydrogenase inhibitors and fibroblast growth factor receptor inhibitors have been shown. In the adjuvant setting, capecitabine monotherapy has become the standard of care in Western countries. In addition to conventional cytotoxic agents, molecular-targeted agents and immunotherapy have been evaluated in multiple clinical trials. Genetic testing is used to check for genetic alterations and molecular-targeted agents and immunotherapy are introduced based on tumor characteristics. In this article, we review the latest evidence of chemotherapy for biliary tract cancer. View Full-Text
Keywords: biliary tract cancer; cholangiocarcinoma; chemotherapy; cytotoxic agents; molecular targeted agents; immunotherapy; precision medicine; genetic testing biliary tract cancer; cholangiocarcinoma; chemotherapy; cytotoxic agents; molecular targeted agents; immunotherapy; precision medicine; genetic testing
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MDPI and ACS Style

Sasaki, T.; Takeda, T.; Okamoto, T.; Ozaka, M.; Sasahira, N. Chemotherapy for Biliary Tract Cancer in 2021. J. Clin. Med. 2021, 10, 3108.

AMA Style

Sasaki T, Takeda T, Okamoto T, Ozaka M, Sasahira N. Chemotherapy for Biliary Tract Cancer in 2021. Journal of Clinical Medicine. 2021; 10(14):3108.

Chicago/Turabian Style

Sasaki, Takashi, Tsuyoshi Takeda, Takeshi Okamoto, Masato Ozaka, and Naoki Sasahira. 2021. "Chemotherapy for Biliary Tract Cancer in 2021" Journal of Clinical Medicine 10, no. 14: 3108.

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