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Article

Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial

1
Doctoral Program in Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Avenida Atenas s/n, 28922 Alcorcón, Madrid, Spain
2
Practice of Dentistry and Halitosis at Core Centro Dental, 28001 Madrid, Spain
3
Faculty of Dentistry, Alfonso X el Sabio University, Villanueva de la Cañada, 28691 Madrid, Spain
4
Department of Medicine Specialties and Public Health, Faculty of Health Sciences, Rey Juan Carlos University, Avenida de Atenas s/n, 28922 Alcorcón, Madrid, Spain
5
IDIBO Group, Health, IDIBO Group (Research, Development and Innovation Group in Dental Biomaterials), Rey Juan Carlos University, Avenida de Atenas s/n, 28922 Alcorcón, Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Gianrico Spagnuolo and Denis Bourgeois
J. Clin. Med. 2021, 10(11), 2256; https://doi.org/10.3390/jcm10112256
Received: 3 April 2021 / Revised: 14 May 2021 / Accepted: 21 May 2021 / Published: 23 May 2021
(This article belongs to the Special Issue Breath Odor and Oral Cavity)
Background: Halitosis of oral origin is very common in the general population. Due to their antimicrobial properties, chlorhexidine-based products are widely used in the management of this condition, but these are associated with reversible side effects. In this study we evaluated the efficacy of Lacer HaliTM mouthrinse and toothpaste in subjects with intraoral halitosis after several applications under normal conditions of use. Methods: In this randomized clinical trial with mouth rinse and toothpaste, single-center, double-blinded, parallel participants were assigned to an experimental group (Lacer HaliTM,, n = 20), a positive control group (HalitaTM, n = 20), and a placebo group (n = 20). The active duration of the study was 18 days. The clinical follow-up evaluations were performed at five time points (T0, T1, T2, T3, and T4). The intensity of halitosis was evaluated by organoleptic measurement and the portable gas chromatograph OralChromaTM. The data were analyzed using generalized mixed linear models. Results: Sixty patients completed the study. Lacer HaliTM, in comparison with HalitaTM, did not show statistically significant differences at any time during the study except for the levels of hydrogen sulfide and total volatile sulfur compounds at 15 days, where HalitaTM was better. Compared to the placebo treatment, Lacer HaliTM, was significantly more efficient, in terms of both the organoleptic evaluations at 8 days and the levels of hydrogen sulfide. Conclusions: Lacer HaliTM is an alternative to chlorhexidine-based toothpaste and mouthwashes in the management of halitosis. View Full-Text
Keywords: halitosis; oral malodor; octenidine; Lacer HaliTM; organoleptic score; OralChromaTM halitosis; oral malodor; octenidine; Lacer HaliTM; organoleptic score; OralChromaTM
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MDPI and ACS Style

Xiang, L.; Rojo, R.; Prados-Frutos, J.C. Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial. J. Clin. Med. 2021, 10, 2256. https://doi.org/10.3390/jcm10112256

AMA Style

Xiang L, Rojo R, Prados-Frutos JC. Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial. Journal of Clinical Medicine. 2021; 10(11):2256. https://doi.org/10.3390/jcm10112256

Chicago/Turabian Style

Xiang, Laiqi, Rosa Rojo, and Juan C. Prados-Frutos. 2021. "Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial" Journal of Clinical Medicine 10, no. 11: 2256. https://doi.org/10.3390/jcm10112256

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