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Volume 11
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10.3390/membranes11100796
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Review

Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity

by
Yi-An Chen
1,2,
Cheng-Hsiu Lu
3,4,
Chien-Chih Ke
5,6,7 and
Ren-Shyan Liu
1,8,9,*
1
Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan
2
Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 112, Taiwan
3
Core Laboratory for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
4
Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5
Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
9
National PET and Cyclotron Center (NPCC), Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
Membranes 2021, 11(10), 796; https://doi.org/10.3390/membranes11100796
Submission received: 23 September 2021 / Revised: 16 October 2021 / Accepted: 16 October 2021 / Published: 19 October 2021
(This article belongs to the Special Issue Shedding New Light on the Cell Biology and Medicine of Extracellular Vesicles)
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Abstract

Alzheimer’s disease (AD), as a neurodegenerative disorder, is characterized by mass neuronal and synaptic loss and, currently, there are no successful curative therapies. Extracellular vesicles (EVs) are an emerging approach to intercellular communication via transferring cellular materials such as proteins, lipids, mRNAs, and miRNAs from parental cells to recipient cells, leading to the reprogramming of the molecular machinery. Numerous studies have suggested the therapeutic potential of EVs derived from mesenchymal stem cells (MSCs) in the treatment of AD, based on the neuroprotective, regenerative and immunomodulatory effects as effective as MSCs. In this review, we focus on the biology and function of EVs, the potential of MSC-derived EVs for AD therapy in preclinical and clinical studies, as well as the potent mechanisms of MSC-derived EVs actions. Finally, we highlight the modification strategies and diagnosis utilities in order to make advance in this field.
Keywords: Alzheimer’s disease; mesenchymal stem cells; extracellular vesicles; therapy Alzheimer’s disease; mesenchymal stem cells; extracellular vesicles; therapy

Share and Cite

MDPI and ACS Style

Chen, Y.-A.; Lu, C.-H.; Ke, C.-C.; Liu, R.-S. Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity. Membranes 2021, 11, 796. https://doi.org/10.3390/membranes11100796

AMA Style

Chen Y-A, Lu C-H, Ke C-C, Liu R-S. Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity. Membranes. 2021; 11(10):796. https://doi.org/10.3390/membranes11100796

Chicago/Turabian Style

Chen, Yi-An, Cheng-Hsiu Lu, Chien-Chih Ke, and Ren-Shyan Liu. 2021. "Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity" Membranes 11, no. 10: 796. https://doi.org/10.3390/membranes11100796

APA Style

Chen, Y.-A., Lu, C.-H., Ke, C.-C., & Liu, R.-S. (2021). Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity. Membranes, 11(10), 796. https://doi.org/10.3390/membranes11100796

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