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Macropinocytosis in Different Cell Types: Similarities and Differences

The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne 3010, Victoria, Australia
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Membranes 2020, 10(8), 177; https://doi.org/10.3390/membranes10080177
Received: 8 July 2020 / Revised: 29 July 2020 / Accepted: 30 July 2020 / Published: 3 August 2020
(This article belongs to the Special Issue Membrane Transport and Cytoskeleton Dynamics)
Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific internalisation of large amounts of extracellular fluid, solutes and membrane in large endocytic vesicles known as macropinosomes. Macropinocytosis is important in a range of physiological processes, including antigen presentation, nutrient sensing, recycling of plasma proteins, migration and signalling. It has become apparent in recent years from the study of specialised cells that there are multiple pathways of macropinocytosis utilised by different cell types, and some of these pathways are triggered by different stimuli. Understanding the physiological function of macropinocytosis requires knowledge of the regulation and fate of the macropinocytosis pathways in a range of cell types. Here, we compare the mechanisms of macropinocytosis in different primary and immortalised cells, identify the gaps in knowledge in the field and discuss the potential approaches to analyse the function of macropinocytosis in vivo. View Full-Text
Keywords: macropinocytosis; macropinosomes; membrane ruffling; dendritic cells; macrophages; endothelial cells; epithelial cells; neurons; microglia; cancer cells; amiloride macropinocytosis; macropinosomes; membrane ruffling; dendritic cells; macrophages; endothelial cells; epithelial cells; neurons; microglia; cancer cells; amiloride
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MDPI and ACS Style

Lin, X.P.; Mintern, J.D.; Gleeson, P.A. Macropinocytosis in Different Cell Types: Similarities and Differences. Membranes 2020, 10, 177.

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