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Article

A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity

1
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
2
Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan
3
Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan
4
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
5
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350, Taiwan
6
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(4), 620; https://doi.org/10.3390/vaccines8040620
Received: 22 September 2020 / Revised: 14 October 2020 / Accepted: 18 October 2020 / Published: 21 October 2020
(This article belongs to the Special Issue Cancer Vaccine)
Peptide vaccines are safe, and aim to elicit and expand tumor-specific immunity so as to eradicate tumors. However, achieving strong and long-lasting anti-tumor immunity with peptide vaccines for the antigen-specific treatment of cancer is challenging, in part because their efficacy depends on strong adjuvants or immunomodulators. We approached this problem by conjugating an epitope-based cancer vaccine with a lipidated sequence (an immunomodulator) to elicit a strong immune response. Lipidated and non-lipidated polyepitope proteins were generated that contained the universal T helper cell epitope (pan-DR), B cell epitopes, and the extended loop sequence of extracellular domain 2 of tumor-associated antigen L6 (TAL6). We show that the lipidated polyepitope cancer vaccine can activate bone marrow-derived dendritic cells, and trigger effective antigen-specific antibody and T helper cell responses, more effectively than the non-lipidated vaccine. Moreover, potent T cell immune responses were elicited in mice inoculated with the lipidated polyepitope cancer vaccine, providing protective antitumor immunity in mice bearing TAL6 tumors. Our study demonstrates that a lipidated polyepitope cancer vaccine could be employed to generate potent anti-tumor immune responses, including humoral and cellular immunity, which could be beneficial in the treatment of TAL6+ cancer. View Full-Text
Keywords: TAL6; lipoprotein; TLR2 TAL6; lipoprotein; TLR2
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MDPI and ACS Style

Sher, Y.-P.; Chai, K.M.; Chen, W.-C.; Shen, K.-Y.; Chen, I.-H.; Lee, M.-H.; Chiu, F.-F.; Liu, S.-J. A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity. Vaccines 2020, 8, 620. https://doi.org/10.3390/vaccines8040620

AMA Style

Sher Y-P, Chai KM, Chen W-C, Shen K-Y, Chen I-H, Lee M-H, Chiu F-F, Liu S-J. A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity. Vaccines. 2020; 8(4):620. https://doi.org/10.3390/vaccines8040620

Chicago/Turabian Style

Sher, Yuh-Pyng, Kit M. Chai, Wen-Ching Chen, Kuan-Yin Shen, I-Hua Chen, Ming-Hui Lee, Fang-Feng Chiu, and Shih-Jen Liu. 2020. "A Polypeptide of Tumor-Associated Antigen L6 with Intrinsic Adjuvant Activity Enhances Antitumor Immunity" Vaccines 8, no. 4: 620. https://doi.org/10.3390/vaccines8040620

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