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Article

Protective Effect of Inactivated COVID-19 Vaccines against Progression of SARS-CoV-2 Omicron and Delta Variant Infections to Pneumonia in Beijing, China, in 2022

1
Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China
2
Beijing Ditan Hospital, Capital Medical University, Beijing 100013, China
3
Beijing Municipal Health Commission, Beijing 100101, China
4
Xicheng Distract Center for Diseases Control and Prevention, Beijing 100120, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: S. Louise Cosby
Vaccines 2022, 10(8), 1215; https://doi.org/10.3390/vaccines10081215
Received: 14 June 2022 / Revised: 18 July 2022 / Accepted: 25 July 2022 / Published: 29 July 2022
(This article belongs to the Special Issue Effectiveness, Safety and Immunogenicity of SARS-CoV-2 Vaccines)
This real-world study explores the effect of coronavirus disease 2019 (COVID-19) inactivated vaccines on the prevention of asymptomatic or mild Delta or Omicron variant infections progressing to pneumonia. Association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases and vaccination was measured with a multivariable logistic regression, stratified by genotype and age groups. We recruited 265 cases (111 (41.9%) infected with Delta and 154 (58.1%) with Omicron variants). There were 22 asymptomatic infected individuals, 156 mild cases without pneumonia, and 87 moderate cases with pneumonia. There was a markedly increased risk of progression to pneumonia in Delta infected cases, unvaccinated, or partially vaccinated COVID-19 patients with diabetes and those aged ≥60 years. Patients who had completed booster doses of inactivated vaccines had a reduced risk of 81.6% (95% CI: 55.6–92.4%) in progressing to pneumonia over those who were unvaccinated or partially vaccinated. The risk of progressing to pneumonia was less reduced by 88.7% (95% CI: 56.6–97%) and 73.9% (95% CI: 1.4–93.1%) among Delta and Omicron-infected patients, and was reduced by 78.5% (95% CI: 45.3–91.6%) and 94.1% (95% CI: 21.5–99.6%) among patients aged <60 and ≥60 years, respectively. Our data indicated that a complete vaccination with a booster reduced the risk of asymptomatic or mild Delta or Omicron variant COVID-19 progressing to pneumonia and, thus, reduced the pressure of severe illness on medical resources. View Full-Text
Keywords: COVID-19; Omicron; Delta; pneumonia; inactive vaccine; effect COVID-19; Omicron; Delta; pneumonia; inactive vaccine; effect
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MDPI and ACS Style

Li, J.; Song, R.; Yuan, Z.; Xu, Z.; Suo, L.; Wang, Q.; Li, Y.; Gao, Y.; Li, X.; Chen, X.; Wu, J. Protective Effect of Inactivated COVID-19 Vaccines against Progression of SARS-CoV-2 Omicron and Delta Variant Infections to Pneumonia in Beijing, China, in 2022. Vaccines 2022, 10, 1215. https://doi.org/10.3390/vaccines10081215

AMA Style

Li J, Song R, Yuan Z, Xu Z, Suo L, Wang Q, Li Y, Gao Y, Li X, Chen X, Wu J. Protective Effect of Inactivated COVID-19 Vaccines against Progression of SARS-CoV-2 Omicron and Delta Variant Infections to Pneumonia in Beijing, China, in 2022. Vaccines. 2022; 10(8):1215. https://doi.org/10.3390/vaccines10081215

Chicago/Turabian Style

Li, Juan, Rui Song, Zheng Yuan, Zheng Xu, Luodan Suo, Qing Wang, Yuan Li, Yanlin Gao, Xiaomei Li, Xiaoyou Chen, and Jiang Wu. 2022. "Protective Effect of Inactivated COVID-19 Vaccines against Progression of SARS-CoV-2 Omicron and Delta Variant Infections to Pneumonia in Beijing, China, in 2022" Vaccines 10, no. 8: 1215. https://doi.org/10.3390/vaccines10081215

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