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Brief Report

Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection

1
Immunology and Vaccinology Research Laboratory and Infectious Diseases Department “MAKKA”, First Department of Paediatrics, “Aghia Sophia” Children’s Hospital, Athens Medical School, 11527 Athens, Greece
2
Athens Medical School, University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
3
Department of Microbiology, Athens Medical School, 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Angelos Hatzakis, Dimitrios Paraskevis and Martin H. Bluth
Vaccines 2022, 10(8), 1210; https://doi.org/10.3390/vaccines10081210
Received: 20 June 2022 / Revised: 16 July 2022 / Accepted: 26 July 2022 / Published: 29 July 2022
(This article belongs to the Special Issue Effectiveness, Safety and Immunogenicity of SARS-CoV-2 Vaccines)
Humoral immunity after SARS-CoV-2 immunization or natural infection is thought to be evanescent. In our study, we aimed to longitudinally characterize the kinetics of antibody titers after dual BNT162b2 immunization or wild-type infection. Vaccinated and recovered individuals displayed distinct antibody kinetics, as convalescents had detectable RBD-, S1-specific, and neutralizing IgG antibody titers two weeks post-infection that gradually increased longitudinally, while RBD-, S1-specific, and neutralizing IgG were detected in vaccinees after the first dose, increased significantly 3 weeks post the second dose and decreased significantly 4–5 months thereafter. Neutralizing IgG was significantly higher initially in convalescent individuals; however, vaccines displayed significantly higher neutralizing antibodies 4–5 months post the second dose. In both groups, there was a strong negative association between elapsed time and antibody levels. The avidity of anti-RBD antibody titers increased significantly in patients longitudinally, while in vaccinees initially increased, with subsequent decrease, remaining however higher than antibody avidity of recovered individuals at all time-points. Anti-RBD antibodies were strongly correlated with neutralizing and anti-S1 antibodies in both groups at all time-points. This study facilitates our further understanding of immune response to SARS-CoV-2 and vaccines. View Full-Text
Keywords: SARS-CoV-2; COVID-19; BNT162b2; humoral immune response; antibodies SARS-CoV-2; COVID-19; BNT162b2; humoral immune response; antibodies
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MDPI and ACS Style

Lagousi, T.; Routsias, J.; Mavrouli, M.; Papadatou, I.; Geropeppa, M.; Spoulou, V. Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection. Vaccines 2022, 10, 1210. https://doi.org/10.3390/vaccines10081210

AMA Style

Lagousi T, Routsias J, Mavrouli M, Papadatou I, Geropeppa M, Spoulou V. Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection. Vaccines. 2022; 10(8):1210. https://doi.org/10.3390/vaccines10081210

Chicago/Turabian Style

Lagousi, Theano, John Routsias, Maria Mavrouli, Ioanna Papadatou, Maria Geropeppa, and Vana Spoulou. 2022. "Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection" Vaccines 10, no. 8: 1210. https://doi.org/10.3390/vaccines10081210

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