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Article

Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants

1
China National Biotec Group Company Limited, Beijing 100024, China
2
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China
3
MOE Key Laboratory of Protein Science & Collaborative Innovation Center of Biotherapy, School of Medicine, Tsinghua University, Beijing 100084, China
4
Beijing Institute of Biological Products Company Limited, Beijing 100176, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Fernando Rodríguez González
Vaccines 2022, 10(6), 956; https://doi.org/10.3390/vaccines10060956
Received: 23 May 2022 / Revised: 13 June 2022 / Accepted: 14 June 2022 / Published: 16 June 2022
(This article belongs to the Special Issue Advances in COVID-19 Vaccines Development)
It has been reported that the novel coronavirus (COVID-19) has caused more than 286 million cases and 5.4 million deaths to date. Several strategies have been implemented globally, such as social distancing and the development of the vaccines. Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have appeared, such as Alpha, Beta, Gamma, Delta, and Omicron. With the rapid spread of the novel coronavirus and the rapidly changing mutants, the development of a broad-spectrum multivalent vaccine is considered to be the most effective way to defend against the constantly mutating virus. Here, we evaluated the immunogenicity of the multivalent COVID-19 inactivated vaccine. Mice were immunized by multivalent COVID-19 inactivated vaccine, and the neutralizing antibodies in serum were analyzed. The results show that HB02 + Delta + Omicron trivalent vaccine could provide broad spectrum protection against HB02, Beta, Delta, and Omicron virus. Additionally, the different multivalent COVID-19 inactivated vaccines could enhance cellular immunity. Together, our findings suggest that the multivalent COVID-19 inactivated vaccine can provide broad spectrum protection against HB02 and other virus variants in humoral and cellular immunity, providing new ideas for the development of a broad-spectrum COVID-19 vaccine. View Full-Text
Keywords: Beta; Delta; HB02; immunogenicity; multivalent inactivated vaccines; Omicron; SARS-CoV-2 Beta; Delta; HB02; immunogenicity; multivalent inactivated vaccines; Omicron; SARS-CoV-2
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MDPI and ACS Style

Zhang, Y.; Tan, W.; Lou, Z.; Huang, B.; Zhou, W.; Zhao, Y.; Zhang, J.; Liang, H.; Li, N.; Zhu, X.; Ding, L.; Guo, Y.; He, Z.; He, Y.; Wang, Z.; Ma, B.; Ma, M.; Zhao, S.; Chang, Z.; Zhao, X.; Zheng, X.; Wu, G.; Wang, H.; Yang, X. Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants. Vaccines 2022, 10, 956. https://doi.org/10.3390/vaccines10060956

AMA Style

Zhang Y, Tan W, Lou Z, Huang B, Zhou W, Zhao Y, Zhang J, Liang H, Li N, Zhu X, Ding L, Guo Y, He Z, He Y, Wang Z, Ma B, Ma M, Zhao S, Chang Z, Zhao X, Zheng X, Wu G, Wang H, Yang X. Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants. Vaccines. 2022; 10(6):956. https://doi.org/10.3390/vaccines10060956

Chicago/Turabian Style

Zhang, Yuntao, Wenjie Tan, Zhiyong Lou, Baoying Huang, Weimin Zhou, Yuxiu Zhao, Jin Zhang, Hongyang Liang, Na Li, Xiujuan Zhu, Ling Ding, Yancen Guo, Zhenyu He, Yao He, Zhanhui Wang, Bo Ma, Meng Ma, Suhua Zhao, Zhen Chang, Xue Zhao, Xiaotong Zheng, Guizhen Wu, Hui Wang, and Xiaoming Yang. 2022. "Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants" Vaccines 10, no. 6: 956. https://doi.org/10.3390/vaccines10060956

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