A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. ELISA Methods
2.3. Statistical Analysis
3. Results
3.1. Post-Vaccination Seropositivity
3.2. Comparison of Anti-RBD IgG Antibody Titers
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Character | Subcategory | N a | % b | GMT c |
---|---|---|---|---|
Age in years | ≥40 | 26 | 41.3 | |
<40 | 37 | 58.7 | ||
Sex | Male (m d) | 36 | 57.1 | |
Female (f e) | 27 | 42.9 | ||
Naïvef | Pre Vacc h | 39 (23 m,16 f) | 200 | |
1d + 8–12w i | 34 (19 m, 15 f) | 1632.16 | ||
2d + 8–12w j | 16 (10 m, 6 f) | 6607.31 | ||
P.I. g | Pre Vacc | 16 (10 m, 6 f) | 1674.94 | |
1d + 8–12w | 23 (13 m, 10 f) | 4913.5 | ||
2d + 8–12w | 16 (10 m, 6 f) | 9804.6 |
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Gelanew, T.; Mulu, A.; Abebe, M.; Bates, T.A.; Wassie, L.; Teferi, M.; Fentahun, D.; Alemu, A.; Tamiru, F.; Assefa, G.; et al. A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers. Vaccines 2022, 10, 859. https://doi.org/10.3390/vaccines10060859
Gelanew T, Mulu A, Abebe M, Bates TA, Wassie L, Teferi M, Fentahun D, Alemu A, Tamiru F, Assefa G, et al. A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers. Vaccines. 2022; 10(6):859. https://doi.org/10.3390/vaccines10060859
Chicago/Turabian StyleGelanew, Tesfaye, Andargachew Mulu, Markos Abebe, Timothy A. Bates, Liya Wassie, Mekonnen Teferi, Dessalegn Fentahun, Aynalem Alemu, Frehiwot Tamiru, Gebeyehu Assefa, and et al. 2022. "A Single Dose of ChAdOx1 nCoV-19 Vaccine Elicits High Antibody Responses in Individuals with Prior SARS-CoV-2 Infection Comparable to That of Two-Dose-Vaccinated, SARS-CoV-2-Infection-Naïve Individuals: A Longitudinal Study in Ethiopian Health Workers" Vaccines 10, no. 6: 859. https://doi.org/10.3390/vaccines10060859