Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Samples Collection and SARS-CoV-2 Antibody Testing
2.3. Risk Categories of Participants
2.4. Ethical Approval
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Adams, J.G.; Walls, R.M. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA 2020, 323, 1439. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Elfström, K.M.; Blomqvist, J.; Nilsson, P.; Hober, S.; Pin, E.; Månberg, A.; Pimenoff, V.N.; Arroyo Mühr, L.S.; Lundgren, K.C.; Dillner, J. Differences in risk for SARS-CoV-2 infection among healthcare workers. Prev. Med. Rep. 2021, 24, 101518. [Google Scholar] [CrossRef] [PubMed]
- World Health Organization (WHO). Coronavirus Disease (COVID-2019) Situation Reports. Available online: https://www.who.int/emergencies/diseases/novelcoronavirus-2019/situation-reports.coronavirus.jhu.edu/map.html (accessed on 7 September 2021).
- Iversen, K.; Bundgaard, H.; Hasselbalch, R.B.; Kristensen, J.H.; Nielsen, P.B.; Pries-Heje, M.; Knudsen, A.D.; Christensen, C.E.; Fogh, K.; Norsk, J.B.; et al. Risk of COVID-19 in health-care workers in Denmark: An observational cohort study. Lancet Infect. Dis. 2020, 20, 1401–1408. [Google Scholar] [CrossRef]
- Galanis, P.; Vraka, I.; Fragkou, D.; Bilali, A.; Kaitelidou, D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: A systematic review and meta-analysis. J. Hosp. Infect. 2021, 108, 120–134. [Google Scholar] [CrossRef]
- Özdemir, A.; Demir Çuha, M.; Telli Dizman, G.; Alp, A.; Metan, G.; Şener, B. Sağlık Çalışanlarında SARS-CoV-2 Seroprevalansı: Türkiye’deki Bir Üniversite Hastanesi Verilerinin Retrospektif Analizi. Mikrobiyoloji Bul. 2021, 55, 223–232. (In Turkish) [Google Scholar] [CrossRef]
- Kayı, İ.; Madran, B.; Keske, Ş.; Karanfil, Ö.; Arribas, J.R.; Pshenichnaya, N.; Petrosillo, N.; Gönen, M.; Ergönül, Ö. The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: A systematic review and meta-analysis. Clin. Microbiol. Infect. 2021, 27, 1242–1249. [Google Scholar] [CrossRef]
- Madran, B.; Keske, S.; Beşli, Y.; Bozkurt, I.; Ergonul, O. The Risk of SARS-CoV-2 Infection among Healthcare Workers. Infect. Dis. Clin. Microbiol. 2020, 2, 54–60. [Google Scholar] [CrossRef]
- Pınarlık, F.; Genç, Z.; Kapmaz, M.; Tekin, S.; Ergönül, Ö. Risk Groups for SARS-CoV-2 Infection among Healthcare Workers: Community Versus Hospital Transmission. Infect. Dis. Rep. 2021, 13, 724–729. [Google Scholar] [CrossRef]
- Steensels, D.; Oris, E.; Coninx, L.; Nuyens, D.; Delforge, M.-L.; Vermeersch, P.; Heylen, L. Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium. JAMA 2020, 324, 195–197. [Google Scholar] [CrossRef]
- Tanaka, A.; Yamamoto, S.; Miyo, K.; Mizoue, T.; Maeda, K.; Sugiura, W.; Mitsuya, H.; Sugiyama, H.; Ohmagari, N. Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan. J. Infect. 2021, 82, e1–e3. [Google Scholar] [CrossRef]
- Jacob, J.T.; Baker, J.M.; Fridkin, S.K.; Lopman, B.A.; Steinberg, J.P.; Christenson, R.H.; King, B.; Leekha, S.; O’Hara, L.M.; Rock, P.; et al. Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel. JAMA Netw. Open 2021, 4, e211283. [Google Scholar] [CrossRef]
- Garcia-Basteiro, A.L.; Moncunill, G.; Tortajada, M.; Vidal, M.; Guinovart, C.; Jiménez, A.; Santano, R.; Sanz, S.; Méndez, S.; Llupià, A.; et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat. Commun. 2020, 11, 1–9. [Google Scholar] [CrossRef]
- Korth, J.; Wilde, B.; Dolff, S.; Anastasiou, O.E.; Krawczyk, A.; Jahn, M.; Cordes, S.; Ross, B.; Esser, S.; Lindemann, M.; et al. SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patients. J. Clin. Virol. 2020, 128, 104437. [Google Scholar] [CrossRef]
- Bradley, B.T.; Bryan, A.; Fink, S.L.; Goecker, E.A.; Roychoudhury, P.; Huang, M.-L.; Zhu, H.; Chaudhary, A.; Madarampalli, B.; Lu, J.Y.C.; et al. Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity. J. Clin. Microbiol. 2021, 59, e0098921. [Google Scholar] [CrossRef]
- Lipsitch, M.; Dean, N.E. Understanding COVID-19 vaccine efficacy. Science 2020, 370, 763–765. [Google Scholar] [CrossRef]
- Tanriover, M.D.; Doğanay, H.L.; Akova, M.; Güner, H.R.; Azap, A.; Akhan, S.; Köse, Ş.; Erdinç, F.; Akalın, E.H.; Tabak, Ö.F.; et al. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): Interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey. Lancet 2021, 398, 213–222. [Google Scholar] [CrossRef]
- Dhama, K.; Khan, S.; Tiwari, R.; Sircar, S.; Bhat, S.; Malik, Y.S.; Singh, K.P.; Chaicumpa, W.; Bonilla-Aldana, D.K.; Rodriguez-Morales, A.J. Coronavirus Disease 2019-COVID-19. Clin. Microbiol. Rev. 2020, 33, e00028-20. [Google Scholar] [CrossRef]
- Peeling, R.W.; Wedderburn, C.J.; Garcia, P.J.; Boeras, D.; Fongwen, N.; Nkengasong, J.; Sall, A.; Tanuri, A.; Heymann, D.L. Serology testing in the COVID-19 pandemic response. Lancet Infect. Dis. 2020, 20, e245–e249. [Google Scholar] [CrossRef]
- Seow, J.; Graham, C.; Merrick, B.; Acors, S.; Pickering, S.; Steel, K.J.A.; Hemmings, O.; O’Byrne, A.; Kouphou, N.; Galao, R.P.; et al. Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans. Nat. Microbiol. 2020, 5, 1598–1607. [Google Scholar] [CrossRef]
- He, X.; Lau, E.H.Y.; Wu, P.; Deng, X.; Wang, J.; Hao, X.; Lau, Y.C.; Wong, J.Y.; Guan, Y.; Tan, X.; et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat. Med. 2020, 26, 672–675. [Google Scholar] [CrossRef] [Green Version]
- Jeremias, A.; Nguyen, J.; Levine, J.; Pollack, S.; Engellenner, W.; Thakore, A.; Lucore, C. Prevalence of SARS-CoV-2 Infection Among Health Care Workers in a Tertiary Community Hospital. JAMA Intern. Med. 2020, 180, 1707–1709. [Google Scholar] [CrossRef] [PubMed]
- Self, W.H.; Tenforde, M.W.; Stubblefield, W.B.; Feldstein, L.R.; Steingrub, J.S.; Shapiro, N.I.; Ginde, A.A.; Prekker, M.E.; Brown, S.M.; Peltan, I.D.; et al. Seroprevalence of SARS-CoV-2 Among Frontline Health Care Personnel in a Multistate Hospital Network - 13 Academic Medical Centers, April-June 2020. MMWR Morb. Mortal. Wkly. Rep. 2020, 69, 1221–1226. [Google Scholar] [CrossRef] [PubMed]
- Moscola, J.; Sembajwe, G.; Jarrett, M.; Farber, B.; Chang, T.; McGinn, T.; Davidson, K.W.; Northwell Health, C.-R.C. Prevalence of SARS-CoV-2 Antibodies in Health Care Personnel in the New York City Area. JAMA 2020, 324, 893–895. [Google Scholar] [CrossRef] [PubMed]
- Cook, T.M.; Lennane, S. Occupational COVID-19 risk for anaesthesia and intensive care staff – low-risk specialties in a high-risk setting. Anaesthesia 2021, 76, 295–300. [Google Scholar] [CrossRef] [PubMed]
- Cevik, M.; Tate, M.; Lloyd, O.; Maraolo, A.E.; Schafers, J.; Ho, A. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: A systematic review and meta-analysis. Lancet Microbe 2021, 2, e13–e22. [Google Scholar] [CrossRef]
- Talic, S.; Shah, S.; Wild, H.; Gasevic, D.; Maharaj, A.; Ademi, Z.; Li, X.; Xu, W.; Mesa-Eguiagaray, I.; Rostron, J.; et al. Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: Systematic review and meta-analysis. BMJ 2021, 375, e068302. [Google Scholar] [CrossRef] [PubMed]
- Sahu, A.K.; Amrithanand, V.T.; Mathew, R.; Aggarwal, P.; Nayer, J.; Bhoi, S. COVID-19 in health care workers - A systematic review and meta-analysis. Am. J. Emerg. Med. 2020, 38, 1727–1731. [Google Scholar] [CrossRef]
- Sims, M.D.; Maine, G.N.; Childers, K.L.; Podolsky, R.H.; Voss, D.R.; Berkiw-Scenna, N.; Oh, J.; Heinrich, K.E.; Keil, H.; Kennedy, R.H.; et al. Coronavirus Disease 2019 (COVID-19) Seropositivity and Asymptomatic Rates in Healthcare Workers Are Associated with Job Function and Masking. Clin. Infect. Dis. 2021, 73, S154–S162. [Google Scholar] [CrossRef]
- Chou, R.; Dana, T.; Buckley, D.I.; Selph, S.; Fu, R.; Totten, A.M. Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers: A Living Rapid Review. Ann. Intern. Med. 2020, 173, 120–136. [Google Scholar] [CrossRef]
- Liu, M.; Cheng, S.Z.; Xu, K.W.; Yang, Y.; Zhu, Q.T.; Zhang, H.; Yang, D.Y.; Cheng, S.Y.; Xiao, H.; Wang, J.W.; et al. Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: Cross sectional study. BMJ 2020, 369, m2195. [Google Scholar] [CrossRef]
HCWs—n (%) | Seropositive HCWs—n (%) | |
---|---|---|
Age | ||
≤29 | 474 (24) | 88 (18.6) |
30–39 | 690 (24.5) | 137 (19.9) |
40–49 | 561 (28.4) | 102 (18.2) |
50–59 | 224 (11.3) | 35 (15.6) |
≥60 | 25 (1.3) | 3 (12) |
Sex | ||
Female | 1282 (64.9) | 233 (18.2) |
Male | 692 (35.1) | 132 (19.1) |
Profession | ||
Physician | 328 (16.6) | 62 (18.9) |
Nurse | 502 (25.5) | 94 (18.7) |
Healthcare assistant | 313 (15.9) | 61 (19.5) |
Technician | 242 (12.3) | 39 (16.1) |
Administration staff | 173 (8.8) | 31(17.9) |
Secretary | 129 (6.5) | 24 (18.6) |
Medical students | 74 (3.7) | 11 (14.9) |
Employees working in the kitchen service | 50 (2.5) | 13 (26) |
Care workers | 23 (1.2) | 3 (13) |
Other personnel | 136 (6.9) | 25 (18.3) |
Risk Categories | ||
Low risk | 503 (25.5) | 56 (11.1) |
Medium risk | 929 (47.1) | 202 (21.7) |
High risk | 542 (27.5) | 107 (19.7) |
Type of Hospital Unit | ||
Other | 1714 (86.8) | 320 (18.7) |
COVID-19 units | 30 (1.5) | 8 (26.7) |
Intensive care unit (ICU) | 85 (4.3) | 10 (11.8) |
Emergency | 145 (7.3) | 27 (18.6) |
Family History of COVID-19 Disease | ||
Yes | 361 (18.3) | 151 (41.8) |
Univariate Analysis | Multivariate Analysis | |||||
---|---|---|---|---|---|---|
Predictive Variable | OR | 95% CI | p-Value | OR | 95% CI | p-Value |
Age | ||||||
≤29 | 1.00 | 0.594 | 1.00 | 0.547 | ||
30–39 | 1.67 | 0.49–5.71 | 1.08 | 0.77–1.53 | ||
40–49 | 1.81 | 0.53–6.15 | 1.02 | 0.7–1.49 | ||
50–59 | 1.63 | 0.47–5.54 | 0.84 | 0.51–1.37 | ||
≥60 | 1.35 | 0.38–4.78 | 0.74 | 0.20–2.69 | ||
Sex | ||||||
Female | 1.00 | 0.623 | 1.00 | 0.623 | ||
Male | 0.94 | 0.74–1.19 | 0.96 | 0.73–1.27 | ||
Profession | ||||||
Physician | 1.00 | 0.89 | 1.00 | 0.939 | ||
Nurse Nurse | 0.98 | 0.69–1.41 | 0.92 | 0.62–1.37 | ||
Healthcare assistant | 1.03 | 0.7–1.53 | 1.04 | 0.67–1.61 | ||
Technician | 0.82 | 0.53–1.28 | 1.53 | 0.92–2.54 | ||
Administration staff | 0.93 | 0.58–1.5 | 1.6 | 0.93–2.8 | ||
Secretary | 0.98 | 0.68–1.65 | 1.87 | 1.01–3.46 | ||
Medical students | 0.74 | 0.37–1.5 | 0.88 | 0.41–1.9 | ||
Employees working in the kitchen service | 1.5 | 0.75-3 | 1.51 | 0.71–3.2 | ||
Care workers | 0.64 | 0.18–2.23 | 0.76 | 0.22–2.89 | ||
Other personnel | 0.96 | 0.57–1.61 | 1.64 | 0.92–2.93 | ||
Risk Categories | ||||||
Low risk | 1.00 | <0.0001 | 1.00 | <0.0001 | ||
Medium risk | 2.21 | 1.61–3.05 | 2.1 | 1.51–2.92 | ||
High risk | 1.96 | 1.38–2.78 | 1.61 | 1.12–2.32 | ||
Type of Hospital Unit | ||||||
Other | 1.00 | 0.112 | 1.00 | 0.141 | ||
COVID-19 units | 1.58 | 0.69–3.59 | 1.3 | 0.52–3.2 | ||
Intensive care unit (ICU) | 0.58 | 0.29–1.13 | 0.6 | 0.29–1,22 | ||
Emergency | 0.99 | 0.64–1.54 | 0.85 | 0.5–1.42 | ||
Family History of COVID-19 Disease | ||||||
Yes | 4.7 | 3.64–6.05 | <0.0001 | 4.62 | 3.57–6 | <0.0001 |
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Sonmezer, M.C.; Erul, E.; Sahin, T.K.; Rudvan Al, I.; Cosgun, Y.; Korukluoglu, G.; Zengin, H.; Telli Dizman, G.; Inkaya, A.C.; Unal, S. Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey. Vaccines 2022, 10, 258. https://doi.org/10.3390/vaccines10020258
Sonmezer MC, Erul E, Sahin TK, Rudvan Al I, Cosgun Y, Korukluoglu G, Zengin H, Telli Dizman G, Inkaya AC, Unal S. Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey. Vaccines. 2022; 10(2):258. https://doi.org/10.3390/vaccines10020258
Chicago/Turabian StyleSonmezer, Meliha Cagla, Enes Erul, Taha Koray Sahin, Ipek Rudvan Al, Yasemin Cosgun, Gulay Korukluoglu, Humeyra Zengin, Gülçin Telli Dizman, Ahmet Cagkan Inkaya, and Serhat Unal. 2022. "Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey" Vaccines 10, no. 2: 258. https://doi.org/10.3390/vaccines10020258
APA StyleSonmezer, M. C., Erul, E., Sahin, T. K., Rudvan Al, I., Cosgun, Y., Korukluoglu, G., Zengin, H., Telli Dizman, G., Inkaya, A. C., & Unal, S. (2022). Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey. Vaccines, 10(2), 258. https://doi.org/10.3390/vaccines10020258