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Open AccessArticle

Comparative Study of Protective Action of Exogenous 2-Cys Peroxiredoxins (Prx1 and Prx2) Under Renal Ischemia-Reperfusion Injury

1
Laboratory of Mechanisms of Reception, Institute of Cell Biophysics of the Russian Academy of Sciences, PSCBR RAS, 142290 Pushchino, Moscow Region, Russia
2
Faculty of Biological and Medical Physics, Laboratory of Special Medical Equipment, Technology and Pharmaceuticals, Moscow Institute of Physics and Technology (MIPT), 141701 Dolgoprudny, Moscow Region, Russia
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(8), 680; https://doi.org/10.3390/antiox9080680
Received: 29 June 2020 / Revised: 10 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Peroxiredoxin)
The pathogenesis of ischemia-reperfusion (I/R) injuries is based on oxidative stress caused by a sharp increase in the concentration of free radicals, reactive oxygen species (ROS) and secondary products of free radical oxidation of biological macromolecules during reperfusion. Application of exogenous antioxidants lowers the level of ROS in the affected tissues, suppresses or adjusts the course of oxidative stress, thereby substantially reducing the severity of I/R injury. We believe that the use of antioxidant enzymes may be the most promising line of effort since they possess higher efficiency than low molecular weight antioxidants. Among antioxidant enzymes, of great interest are peroxiredoxins (Prx1–6) which reduce a wide range of organic and inorganic peroxide substrates. In an animal model of bilateral I/R injury of kidneys (using histological, biochemical, and molecular biological methods) it was shown that intravenous administration of recombinant typical 2-Cys peroxiredoxins (Prx1 and Prx2) effectively reduces the severity of I/R damage, contributing to the normalization of the structural and functional state of the kidneys and an almost 2-fold increase in the survival of experimental animals. The use of recombinant Prx1 or Prx2 can be an efficient approach for the prevention and treatment of renal I/R injury. View Full-Text
Keywords: peroxiredoxin; antioxidant activity; ischemia-reperfusion; kidney; oxidative stress peroxiredoxin; antioxidant activity; ischemia-reperfusion; kidney; oxidative stress
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MDPI and ACS Style

Sharapov, M.G.; Goncharov, R.G.; Filkov, G.I.; Trofimenko, A.V.; Boyarintsev, V.V.; Novoselov, V.I. Comparative Study of Protective Action of Exogenous 2-Cys Peroxiredoxins (Prx1 and Prx2) Under Renal Ischemia-Reperfusion Injury. Antioxidants 2020, 9, 680.

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