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Comparative Study of Protective Action of Exogenous 2-Cys Peroxiredoxins (Prx1 and Prx2) Under Renal Ischemia-Reperfusion Injury
Article

Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice

1
College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea
2
College of Pharmacy, Graduate School of Applied Science and Technology for Skin Health and Aesthetics, Ewha Womans University, Seoul 120-750, Korea
3
Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
4
Biochemistryand Biophysics Center, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(8), 769; https://doi.org/10.3390/antiox9080769
Received: 29 June 2020 / Revised: 5 August 2020 / Accepted: 12 August 2020 / Published: 18 August 2020
(This article belongs to the Special Issue Peroxiredoxin)
Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury. View Full-Text
Keywords: peroxiredoxin V; reactive oxygen species; renal ischemia/reperfusion; renal dysfunction peroxiredoxin V; reactive oxygen species; renal ischemia/reperfusion; renal dysfunction
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MDPI and ACS Style

Park, J.; Lee, E.G.; Yi, H.J.; Kim, N.H.; Rhee, S.G.; Woo, H.A. Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice. Antioxidants 2020, 9, 769. https://doi.org/10.3390/antiox9080769

AMA Style

Park J, Lee EG, Yi HJ, Kim NH, Rhee SG, Woo HA. Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice. Antioxidants. 2020; 9(8):769. https://doi.org/10.3390/antiox9080769

Chicago/Turabian Style

Park, Jiyoung, Eun G. Lee, Ho J. Yi, Nam H. Kim, Sue G. Rhee, and Hyun A. Woo. 2020. "Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice" Antioxidants 9, no. 8: 769. https://doi.org/10.3390/antiox9080769

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