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Terpenoids as Potential Geroprotectors

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya st., 167982 Syktyvkar, Russia
Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky Prosp., 167001 Syktyvkar, Russia
Initium-Pharm, LTD, 142000 Moscow, Russia
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(6), 529;
Received: 22 May 2020 / Revised: 9 June 2020 / Accepted: 14 June 2020 / Published: 17 June 2020
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases. View Full-Text
Keywords: terpenoids; carotenoids; antioxidants; aging; lifespan; geroprotectors terpenoids; carotenoids; antioxidants; aging; lifespan; geroprotectors
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MDPI and ACS Style

Proshkina, E.; Plyusnin, S.; Babak, T.; Lashmanova, E.; Maganova, F.; Koval, L.; Platonova, E.; Shaposhnikov, M.; Moskalev, A. Terpenoids as Potential Geroprotectors. Antioxidants 2020, 9, 529.

AMA Style

Proshkina E, Plyusnin S, Babak T, Lashmanova E, Maganova F, Koval L, Platonova E, Shaposhnikov M, Moskalev A. Terpenoids as Potential Geroprotectors. Antioxidants. 2020; 9(6):529.

Chicago/Turabian Style

Proshkina, Ekaterina, Sergey Plyusnin, Tatyana Babak, Ekaterina Lashmanova, Faniya Maganova, Liubov Koval, Elena Platonova, Mikhail Shaposhnikov, and Alexey Moskalev. 2020. "Terpenoids as Potential Geroprotectors" Antioxidants 9, no. 6: 529.

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