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Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics

1
Department of Cosmetology, University of Information Technology and Management in Rzeszów, Sucharskiego 2, 35-225 Rzeszów, Poland
2
Department of Pharmacognosy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
3
Department of Clinical Genetics, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(3), 202; https://doi.org/10.3390/antiox9030202
Received: 5 February 2020 / Revised: 21 February 2020 / Accepted: 27 February 2020 / Published: 1 March 2020
(This article belongs to the Section Natural and Synthetic Antioxidants)
Skin is constantly exposed to harmful environmental factors, causing photo-oxidative stress in cells and leading to the development of health and aesthetic problems. Multifunctional ingredients of everyday skincare products, possessing antioxidant, UV-protecting, anti-hyperpigmentation, and skin cancer-preventing properties are in high demand. Due to the high content of polyphenolic compounds Cistus × incanus L. and Cistus ladanifer L. are potentially interesting sources of cosmetic ingredients with multiple skin protecting functions. In this study eight extracts from dried C. incanus and C. ladanifer—aerial parts were prepared using 60% (v/v) or 100% (v/v) methanol, on a magnetic stirrer or in Soxhlet apparatus, and compared for their content of phytochemicals and properties important for the skin protection. Extracts from C. incanus prepared in 60% (v/v) methanol contained the highest amount of polyphenolic compounds (331.82–347.27 mg GAE/g DW) and showed the most significant antioxidant activity (IC50 = 3.81–4.05 µg/mL). C. incanus extracts were also effective tyrosinase inhibitors (30–70% inhibition at 100 µg/mL). Statistical correlation analysis revealed that epicatechin, epigallocatechin gallate (EGCG), and myricitrin may be responsible for the antioxidant and tyrosinase inhibitory potential of C. incanus extracts. All analyzed extracts were cytotoxic for human melanoma cells A375 (IC50 = 57.80–199.01 µg/mL), with C. incanus extract prepared in 100% (v/v) methanol using Soxhlet extraction being the most effective. The extracts did not significantly impair the growth of noncancerous human keratinocytes HaCaT. C. incanus and C. ladanifer extracts possess also natural sun protecting activity (SPF 3.42–3.77 at 100 µg/mL), enhancing their anti-hyperpigmentation and anti-melanoma potential. View Full-Text
Keywords: Cistus incanus; Cistus ladanifer; antioxidant; tyrosinase; melanoma; in vitro cytotoxicity; sun protection factor (SPF) Cistus incanus; Cistus ladanifer; antioxidant; tyrosinase; melanoma; in vitro cytotoxicity; sun protection factor (SPF)
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MDPI and ACS Style

Gaweł-Bęben, K.; Kukula-Koch, W.; Hoian, U.; Czop, M.; Strzępek-Gomółka, M.; Antosiewicz, B. Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics. Antioxidants 2020, 9, 202. https://doi.org/10.3390/antiox9030202

AMA Style

Gaweł-Bęben K, Kukula-Koch W, Hoian U, Czop M, Strzępek-Gomółka M, Antosiewicz B. Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics. Antioxidants. 2020; 9(3):202. https://doi.org/10.3390/antiox9030202

Chicago/Turabian Style

Gaweł-Bęben, Katarzyna, Wirginia Kukula-Koch, Uliana Hoian, Marcin Czop, Marcelina Strzępek-Gomółka, and Beata Antosiewicz. 2020. "Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics" Antioxidants 9, no. 3: 202. https://doi.org/10.3390/antiox9030202

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