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Antioxidants
Volume 9
Issue 12
10.3390/antiox9121277
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Article

Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis

by
Shou-Long Deng
1,
Bao-Lu Zhang
2,
Russel J. Reiter
3,* and
Yi-Xun Liu
4,*
1
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
2
Marine Consulting Center of Natural Resources of the People’s Republic of China, Beijing 100071, China
3
Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA
4
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(12), 1277; https://doi.org/10.3390/antiox9121277
Submission received: 23 November 2020 / Revised: 10 December 2020 / Accepted: 11 December 2020 / Published: 14 December 2020
(This article belongs to the Special Issue Melatonin and Related Compounds: Antioxidant and Anti-inflammatory Actions)
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Abstract

Gram-negative bacterial infections of the testis can lead to infectious orchitis, which negatively influences steroid hormone synthesis and spermatogenesis. Lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall, acts via toll like receptors 4 (TLR4) to trigger innate immune responses and activate nuclear factor kappa B signaling. The protective mechanisms of melatonin on LPS-induced infectious orchitis have not been reported. Herein, we developed an LPS-induced sheep infectious orchitis model. In this model, the phagocytic activity of testicular macrophages (TM) was enhanced after melatonin treatment. Moreover, we found that melatonin suppressed secretion of TM pro-inflammatory factors by suppressing the p38MAPK pathway and promoting Leydig cell testosterone secretion. Expressions of GTP cyclohydrolase-I and NADPH oxidase-2 were reduced by melatonin while heme oxygenase-1 expression was up-regulated. Thus, melatonin reduced the severity of LPS-induced orchitis by stimulating antioxidant activity. The results of this study provide a reference for the treatment of acute infectious orchitis.
Keywords: melatonin; TLR4; testicular macrophages; p38MAPK; sheep melatonin; TLR4; testicular macrophages; p38MAPK; sheep

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MDPI and ACS Style

Deng, S.-L.; Zhang, B.-L.; Reiter, R.J.; Liu, Y.-X. Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis. Antioxidants 2020, 9, 1277. https://doi.org/10.3390/antiox9121277

AMA Style

Deng S-L, Zhang B-L, Reiter RJ, Liu Y-X. Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis. Antioxidants. 2020; 9(12):1277. https://doi.org/10.3390/antiox9121277

Chicago/Turabian Style

Deng, Shou-Long, Bao-Lu Zhang, Russel J. Reiter, and Yi-Xun Liu. 2020. "Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis" Antioxidants 9, no. 12: 1277. https://doi.org/10.3390/antiox9121277

APA Style

Deng, S.-L., Zhang, B.-L., Reiter, R. J., & Liu, Y.-X. (2020). Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis. Antioxidants, 9(12), 1277. https://doi.org/10.3390/antiox9121277

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