Next Article in Journal
On the Origin and Fate of Reactive Oxygen Species in Plant Cell Compartments
Previous Article in Journal
Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Control
Previous Article in Special Issue
Suppression of Light-Induced Retinal Degeneration by Quercetin via the AP-1 Pathway in Rats
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview

Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

1
Unitat predepartamental de Medicina, Universitat Jaume I, 12071 Castellón de la Plana, Spain
2
Departament de Ciències Agràries i del Medi Natural, Universitat Jaume I, 12071 Castellón de la Plana, Spain
3
Departamento de Ciencias Biomédicas, Universidad Europea de Valencia, 46010 Valencia, Spain
4
Universitat Jaume I, Unitat predepartamental de Medicina, Avda/Sos Baynat, S/N, 12071 Castellón de la Plana, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(4), 104; https://doi.org/10.3390/antiox8040104
Received: 28 February 2019 / Revised: 3 April 2019 / Accepted: 13 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Antioxidants and Retinal Disease)
  |  
PDF [837 KB, uploaded 17 April 2019]
  |  

Abstract

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. It has been demonstrated that ABA plays a key role in glucose metabolism, inflammation, memory and tumor growth. This review focuses on a novel and promising role of ABA as a potential modulator of angiogenesis, oxidative status and inflammatory processes in the retina, which are the most predominant characteristics of the IRs. Thus, this nutraceutical compound might shed some light in new therapeutic strategies focused in the prevention or amelioration of IRs-derived pathologies. View Full-Text
Keywords: abscisic acid; ischemic retinopathy; oxidative stress; angiogenesis; inflammation abscisic acid; ischemic retinopathy; oxidative stress; angiogenesis; inflammation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Baliño, P.; Gómez-Cadenas, A.; López-Malo, D.; Romero, F.J.; Muriach, M. Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies? Antioxidants 2019, 8, 104.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top