Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Procedure
2.3. Overlapping Intervals Procedure
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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mda-MCI | na-MCI | sda-MCI | SCCs | Group Differences χ² (gl) | Group Comparisons | |
---|---|---|---|---|---|---|
Age | 72.42 (8.33) | 67.12 (8.82) | 69.29 (9.36) | 65.49 (9.05) | 24.83 ** | mda-MCI > naMCI, SCCs; sda-MCI>SCCs |
Years of education | 9.68 (8.82) | 8.29 (3.75) | 9.40 (4.17) | 9.92 (4.70) | 1.81 | |
Memory complaints—participant | 19.43 (4.69) | 20.35 (3.45) | 19.03 (4.69) | 18.81 (4.51) | 8.53 * | naMCI > SCCs |
Memory complaints—proxy | 17.97 (4.54) | 18.03 (4.76) | 16.84 (4.46) | 15.49 (4.23) | 17.03 ** | mda-MCI, naMCI > sdaMCI, SCCs; sda-MCI > SCCs |
CVLT Short Delay Free Recall | 3.10 (2.03) | 9.18 (2.21) | 3.88 (2.05) | 10.34 (2.70) | 228.58 ** | SCCs, na-MCI > mda-MCI, sda-MCI; sda-MCI > mda-MCI |
CVLT Long Delay Free Recall | 3.82 (3.19) | 9.76 (2.69) | 5.12 (3.06) | 11.14 (2.83) | 184.80 ** | SCCs, sda-MCI, na-MCI > mdaMCI; SCCs> na-MCI, sda-MCI; na-MCI>sda-MCI |
CAMCOG-R memory | 15.50 (3.80) | 18.56 (2.87) | 18.53 (3.88) | 21.26 (2.78) | 99.18 ** | SCCs, sda-MCI, na-MCI > mdaMCI; SCCs > na-MCI, sda-MCI |
CAMCOG-R orientation | 7.98 (1.46) | 9.29 (0.80) | 9.31 (0.83) | 9.64 (0.63) | 79.19 ** | SCCs, sda-MCI, na-MCI > mdaMCI; SCCs > na-MCI, sda-MCI |
CAMCOG-R language | 22.77 (2.36) | 23.53 (2.00) | 24.90 (2.43) | 25.60 (2.40) | 54.55 ** | SCCs, sda-MCI > mdaMCI, na-MCI |
CAMCOG-R attention - calculation | 5.03 (2.21) | 4.29 (1.73) | 7.25 (1.70) | 7.05 (1.97) | 100.90 ** | SCCs, sda-MCI > mdaMCI, na-MCI |
CAMCOG-R praxis | 9.10 (2.53) | 10.03 (1.71) | 10.71 (1.47) | 11.14 (1.19) | 48.01 ** | SCCs, sda-MCI > mdaMCI, na-MCI |
CAMCOG-R perception | 5.97 (1.64) | 6.50 (1.28) | 6.53 (1.48) | 7.06 (1.44) | 21.68 ** | SCCs, sda-MCI > mdaMCI; SCCs > na-MCI, sda-MCI |
CAMCOG-R executive function | 13.22 (3.94) | 15.35 (4.20) | 15.93 (4.28) | 18.42 (4.20) | 58.84 ** | SCCs, sda-MCI > mdaMCI; SCCs > na-MCI, sda-MCI |
Interval | mda-MCI | na-MCI | sda-MCI | SCCs |
---|---|---|---|---|
9–15 months | 6 | 3 | 10 | 35 |
12–18 months | 14 | 15 | 30 | 125 |
15–21 months | 16 | 16 | 31 | 155 |
18–24 months | 13 | 11 | 22 | 105 |
21–27 months | 5 | 8 | 13 | 49 |
24–30 months | 4 | 4 | 7 | 25 |
27–33 months | 6 | 3 | 11 | 47 |
30–36 months | 9 | 7 | 21 | 98 |
33–39 months | 10 | 15 | 21 | 98 |
36–42 months | 8 | 12 | 14 | 56 |
39–45 months | 8 | 8 | 9 | 51 |
42–48 months | 6 | 3 | 9 | 27 |
45–51 months | 4 | 4 | 9 | 18 |
Interval | sda-MCI OR (95% CI) | mda-MCI OR (95% CI) |
---|---|---|
9–15 months | 9 (8.20–9.80) | 3.36 (3.06–3.66) |
12–18 months | 4 (3.35–4.65) | 1 (1.00–2.12) |
15–21 months | 1.62 (1.22–2.02) | 0.41 (0–1.21) |
18–24 months | 5.22 (4.67–5.77) | 1.31 (1.08–1.34) |
21–27 months | 2.39 (1.45–3.34) | 0.41 (0–1.21) |
24–30 months | 2.89 (2.10–3.68) | 1 (1.00–2.12) |
27–33 months | 16 (12.10–19.90) | 5.06 (4.85–5.27) |
30–36 months | 11.56 (10.10–12.45) | 1.96 (1.52–2.40) |
33–39 months | 2.25 (1,10–3.40) | 0.49 (0–1.21) |
36–42 months | 1.51 (1.10–1.92) | 0.48 (0–1.21) |
39–45 months | 1.19 (1.00–1.77) | 1 (1.00–2.12) |
42–48 months | 8.16 (6.80–9.54) | 3.45 (2.90–4.05) |
45–51 months | 3.31 (2.80–3.82) | 1 (1.00–2.12) |
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Facal, D.; Guàrdia-Olmos, J.; Pereiro, A.X.; Lojo-Seoane, C.; Peró, M.; Juncos-Rabadán, O. Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes. Brain Sci. 2019, 9, 242. https://doi.org/10.3390/brainsci9090242
Facal D, Guàrdia-Olmos J, Pereiro AX, Lojo-Seoane C, Peró M, Juncos-Rabadán O. Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes. Brain Sciences. 2019; 9(9):242. https://doi.org/10.3390/brainsci9090242
Chicago/Turabian StyleFacal, David, Joan Guàrdia-Olmos, Arturo X. Pereiro, Cristina Lojo-Seoane, Maribel Peró, and Onésimo Juncos-Rabadán. 2019. "Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes" Brain Sciences 9, no. 9: 242. https://doi.org/10.3390/brainsci9090242