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Open AccessArticle

Long-Term Satisfaction and Patient-Centered Outcomes of Deep Brain Stimulation in Parkinson’s Disease

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Movement Disorder Section of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Suite 755; Chicago, IL 60612, USA
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Department of Neurological Sciences, Loyola University Medical Center, 2160 S. 1st Ave.; Maywood, IL 60153, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(4), 60; https://doi.org/10.3390/brainsci8040060
Received: 21 March 2018 / Revised: 27 March 2018 / Accepted: 30 March 2018 / Published: 1 April 2018
Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective and proven treatment option for patients with advanced Parkinson’s disease (PD). Long-term outcomes (>5 years) have demonstrated sustained improvement in objective motor symptoms; however, few studies have evaluated patient-centered outcomes other than quality of life (QOL). A locally developed DBS-patient-centered outcomes questionnaire was administered to PD patients >5 years post-DBS. All questions were scored on a ten-point scale, whereby 0 represented the most ‘positive’ answer and 10 the most ‘negative’ answer. Pre-operative scales were repeated at the time of survey. Fifty-two patients (mean 8.2 ± 2.6 years post-DBS) were included. Satisfaction was high with median score (range) of 1/10 (0–8) at the time of survey. Patients endorsed having made the correct decision by undergoing DBS, with a score of 0 (0–10), would choose to have DBS again, with a score of 0 (0–10), and would recommend DBS to others, with a score of 0 (0–10). Pre-operative expectation target was set at a high level with a score of 2 (0–10). Parkinson’s Disease QOL (PDQ-39) Questionnaire Summary Index (SI) scores were, mean (SD), 2.1 (18.2) above baseline (p = 0.44). Those with worsening in PDQ-39-SI scores had less satisfaction with DBS (rs = 0.57, p ≤ 0.0001). This is the first study to assess long-term patient satisfaction with STN DBS. We are currently collecting data prospectively to confirm the results of these preliminary findings. View Full-Text
Keywords: deep brain stimulation; Parkinson’s disease; subthalamic nucleus; patient-centered outcomes; quality of life; satisfaction; long term deep brain stimulation; Parkinson’s disease; subthalamic nucleus; patient-centered outcomes; quality of life; satisfaction; long term
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Karl, J.A.; Ouyang, B.; Colletta, K.; Verhagen Metman, L. Long-Term Satisfaction and Patient-Centered Outcomes of Deep Brain Stimulation in Parkinson’s Disease. Brain Sci. 2018, 8, 60.

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