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The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications

by Nelson B. Rodrigues 1,2,3,†, Karim Mithani 1,2,†, Ying Meng 1,2,3, Nir Lipsman 1,2,4 and Clement Hamani 1,2,4,*
1
Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada
2
Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
3
Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada
4
Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
*
Author to whom correspondence should be addressed.
Both N.B.R. and K.M. contributed equally to this work.
Brain Sci. 2018, 8(2), 23; https://doi.org/10.3390/brainsci8020023
Received: 9 December 2017 / Revised: 24 January 2018 / Accepted: 26 January 2018 / Published: 29 January 2018
Diffusion tensor imaging (DTI) is an MRI-based technique that delineates white matter tracts in the brain by tracking the diffusion of water in neural tissue. This methodology, known as “tractography”, has been extensively applied in clinical neuroscience to explore nervous system architecture and diseases. More recently, tractography has been used to assist with neurosurgical targeting in functional neurosurgery. This review provides an overview of DTI principles, and discusses current applications of tractography for improving and helping develop novel deep brain stimulation (DBS) targets. View Full-Text
Keywords: diffusion tensor imaging; tractography; deep brain stimulation; tremor; depression diffusion tensor imaging; tractography; deep brain stimulation; tremor; depression
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Rodrigues, N.B.; Mithani, K.; Meng, Y.; Lipsman, N.; Hamani, C. The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications. Brain Sci. 2018, 8, 23.

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