Next Article in Journal
Global Neural Activities Changes under Human Inhibitory Control Using Translational Scenario
Previous Article in Journal
Differentiating High-Grade Gliomas from Brain Metastases at Magnetic Resonance: The Role of Texture Analysis of the Peritumoral Zone
Previous Article in Special Issue
Evaluating the Impact of Age, Acoustic Exposure, and Electrical Stimulation on Binaural Sensitivity in Adult Bilateral Cochlear Implant Patients
Open AccessReview

Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms

Institute of Neurosciences of Castilla y León, University of Salamanca, 37007 Salamanca, Spain
Institute Biomedical Research of Salamanca, University Hospital of Salamanca, 37007 Salamanca, Spain
Department of Cell Biology and Pathology, University of Salamanca, 37008 Salamanca, Spain
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(9), 639;
Received: 11 August 2020 / Revised: 9 September 2020 / Accepted: 14 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue Central Auditory Plasticity)
When a low-salience stimulus of any type of sensory modality—auditory, visual, tactile—immediately precedes an unexpected startle-like stimulus, such as the acoustic startle reflex, the startle motor reaction becomes less pronounced or is even abolished. This phenomenon is known as prepulse inhibition (PPI), and it provides a quantitative measure of central processing by filtering out irrelevant stimuli. As PPI implies plasticity of a reflex and is related to automatic or attentional processes, depending on the interstimulus intervals, this behavioral paradigm might be considered a potential marker of short- and long-term plasticity. Assessment of PPI is directly related to the examination of neural sensorimotor gating mechanisms, which are plastic-adaptive operations for preventing overstimulation and helping the brain to focus on a specific stimulus among other distracters. Despite their obvious importance in normal brain activity, little is known about the intimate physiology, circuitry, and neurochemistry of sensorimotor gating mechanisms. In this work, we extensively review the current literature focusing on studies that used state-of-the-art techniques to interrogate the neuroanatomy, connectomics, neurotransmitter-receptor functions, and sex-derived differences in the PPI process, and how we can harness it as biological marker in neurological and psychiatric pathology. View Full-Text
Keywords: attentional modulations; neuroplasticity; PPI attentional modulations; neuroplasticity; PPI
Show Figures

Graphical abstract

MDPI and ACS Style

Gómez-Nieto, R.; Hormigo, S.; López, D.E. Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms. Brain Sci. 2020, 10, 639.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop