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Article

A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats

1
Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia
2
Research and Clinical Center for Neuropsychiatry of Moscow Healthcare Department, 43 Donskaya Str., 115419 Moscow, Russia
3
Sklifosovsky Research Institute of Emergency Care, 3 Bolshaya Sucharevskaya Square, 129010 Moscow, Russia
4
Department of Neurosurgery and Neuroresuscitation, Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya Str., 127473 Moscow, Russia
*
Author to whom correspondence should be addressed.
These authors equally contributed to this study.
Brain Sci. 2020, 10(9), 570; https://doi.org/10.3390/brainsci10090570
Received: 30 June 2020 / Revised: 14 August 2020 / Accepted: 14 August 2020 / Published: 19 August 2020
(This article belongs to the Special Issue The Molecular and Cellular Mechanisms of Epilepsy)
Background: In humans, early pathological activity on invasive electrocorticograms (ECoGs) and its putative association with pathomorphology in the early period of traumatic brain injury (TBI) remains obscure. Methods: We assessed pathological activity on scalp electroencephalograms (EEGs) and ECoGs in patients with acute TBI, early electrophysiological changes after lateral fluid percussion brain injury (FPI), and electrophysiological correlates of hippocampal damage (microgliosis and neuronal loss), a week after TBI in rats. Results: Epileptiform activity on ECoGs was evident in 86% of patients during the acute period of TBI, ECoGs being more sensitive to epileptiform and periodic discharges. A “brush-like” ECoG pattern superimposed over rhythmic delta activity and periodic discharge was described for the first time in acute TBI. In rats, FPI increased high-amplitude spike incidence in the neocortex and, most expressed, in the ipsilateral hippocampus, induced hippocampal microgliosis and neuronal loss, ipsilateral dentate gyrus being most vulnerable, a week after TBI. Epileptiform spike incidence correlated with microglial cell density and neuronal loss in the ipsilateral hippocampus. Conclusion: Epileptiform activity is frequent in the acute period of TBI period and is associated with distant hippocampal damage on a microscopic level. This damage is probably involved in late consequences of TBI. The FPI model is suitable for exploring pathogenetic mechanisms of post-traumatic disorders. View Full-Text
Keywords: traumatic brain injury; post-traumatic epilepsy; epileptiform discharges; electrocorticograms; local field potentials; neocortex; hippocampus; microglia; neurodegeneration traumatic brain injury; post-traumatic epilepsy; epileptiform discharges; electrocorticograms; local field potentials; neocortex; hippocampus; microglia; neurodegeneration
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MDPI and ACS Style

Komoltsev, I.G.; Sinkin, M.V.; Volkova, A.A.; Smirnova, E.A.; Novikova, M.R.; Kordonskaya, O.O.; Talypov, A.E.; Guekht, A.B.; Krylov, V.V.; Gulyaeva, N.V. A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats. Brain Sci. 2020, 10, 570. https://doi.org/10.3390/brainsci10090570

AMA Style

Komoltsev IG, Sinkin MV, Volkova AA, Smirnova EA, Novikova MR, Kordonskaya OO, Talypov AE, Guekht AB, Krylov VV, Gulyaeva NV. A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats. Brain Sciences. 2020; 10(9):570. https://doi.org/10.3390/brainsci10090570

Chicago/Turabian Style

Komoltsev, Ilia G., Mikhail V. Sinkin, Aleksandra A. Volkova, Elizaveta A. Smirnova, Margarita R. Novikova, Olga O. Kordonskaya, Alexander E. Talypov, Alla B. Guekht, Vladimir V. Krylov, and Natalia V. Gulyaeva 2020. "A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats" Brain Sciences 10, no. 9: 570. https://doi.org/10.3390/brainsci10090570

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