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Open AccessArticle

In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures

1
Biological Faculty, Saint Petersburg State University, St Petersburg 199034, Russia
2
Institute of Translational Biomedicine, Saint Petersburg State University, St Petersburg 199034, Russia
3
School of Medicine, University of Maryland, Baltimore, MD 21201, USA
4
Department of Physiology, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA
*
Authors to whom correspondence should be addressed.
Brain Sci. 2020, 10(12), 942; https://doi.org/10.3390/brainsci10120942
Received: 14 October 2020 / Revised: 29 November 2020 / Accepted: 30 November 2020 / Published: 7 December 2020
(This article belongs to the Special Issue The Molecular and Cellular Mechanisms of Epilepsy)
Epilepsy remains one of the most common brain disorders, and the different types of epilepsy encompass a wide variety of physiological manifestations. Clinical and preclinical findings indicate that cerebral blood flow is usually focally increased at seizure onset, shortly after the beginning of ictal events. Nevertheless, many questions remain about the relationship between vasomotor changes in the epileptic foci and the epileptic behavior of neurons and astrocytes. To study this relationship, we performed a series of in vitro and in vivo experiments using the 4-aminopyridine model of epileptic seizures. It was found that in vitro pathological synchronization of neurons and the depolarization of astrocytes is accompanied by rapid short-term vasoconstriction, while in vivo vasodilation during the seizure prevails. We suggest that vasomotor activity during epileptic seizures is a correlate of the complex, self-sustained response that includes neuronal and astrocytic oscillations, and that underlies the clinical presentation of epilepsy. View Full-Text
Keywords: astrocytes; cerebral blood circulation; epilepsy; epileptic seizures; vasoconstriction; vasodilation; vasomotor activity; 4-aminopyridine astrocytes; cerebral blood circulation; epilepsy; epileptic seizures; vasoconstriction; vasodilation; vasomotor activity; 4-aminopyridine
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MDPI and ACS Style

Volnova, A.; Tsytsarev, V.; Ptukha, M.; Inyushin, M. In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures. Brain Sci. 2020, 10, 942. https://doi.org/10.3390/brainsci10120942

AMA Style

Volnova A, Tsytsarev V, Ptukha M, Inyushin M. In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures. Brain Sciences. 2020; 10(12):942. https://doi.org/10.3390/brainsci10120942

Chicago/Turabian Style

Volnova, Anna; Tsytsarev, Vassiliy; Ptukha, Maria; Inyushin, Mikhail. 2020. "In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures" Brain Sci. 10, no. 12: 942. https://doi.org/10.3390/brainsci10120942

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