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Neurodevelopmental Consequences of Pediatric Cancer and Its Treatment: The Role of Sleep

1
Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia, 27100 Pavia, Italy
2
Department of Developmental and Social Psychology, Sapienza University, 00185 Rome, Italy
3
Pulmonary and Sleep Medicine, University of Washington, Seattle Children’s Hospital, Seattle, WA 98105, USA
4
Sleep Research Centre, Department of Neurology I.C., Oasi Research Institute—IRCCS, 94018 Troina, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(7), 411; https://doi.org/10.3390/brainsci10070411
Received: 13 May 2020 / Revised: 15 June 2020 / Accepted: 22 June 2020 / Published: 1 July 2020
(This article belongs to the Special Issue Neurodevelopmental Problems and Neurometabolic Disorders in Childhood)
Cognitive impairment is frequent in pediatric cancer, and behavioral and psychological disturbances often also affect children who have survived cancer problems. Furthermore, pediatric tumors are also often associated with sleep disorders. The interrelationship between sleep disorders, neurodevelopmental disorders and pediatric cancer, however, is still largely unexplored. In this narrative review we approach this important aspect by first considering studies on pediatric cancer as a possible cause of neurodevelopmental disorders and then describing pediatric cancer occurring as a comorbid condition in children with neurodevelopmental disorders. Finally, we discuss the role of sleep disorders in children with cancer and neurodevelopmental disorders. Even if the specific literature approaching directly the topic of the role of sleep in the complex relationship between pediatric cancer and neurodevelopmental disorders was found to be scarce, the available evidence supports the idea that in-depth knowledge and correct management of sleep disorders can definitely improve the health and quality of life of children with cancer and of their families. View Full-Text
Keywords: neurodevelopmental disorders; intellectual disability; neurocognitive deficit; sleep; cancer; tumor neurodevelopmental disorders; intellectual disability; neurocognitive deficit; sleep; cancer; tumor
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MDPI and ACS Style

Mogavero, M.P.; Bruni, O.; DelRosso, L.M.; Ferri, R. Neurodevelopmental Consequences of Pediatric Cancer and Its Treatment: The Role of Sleep. Brain Sci. 2020, 10, 411.

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