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Volume 10
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Communication

Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study

by
Artur Reginia
1,*,
Jerzy Samochowiec
1,
Marcin Jabłoński
1,
Ewa Ferensztajn-Rochowiak
2,
Janusz K. Rybakowski
2,3,
Arkadiusz Telesiński
4,
Maciej Tarnowski
5,
Błażej Misiak
6,
Mariusz Z. Ratajczak
7,8 and
Jolanta Kucharska-Mazur
1
1
Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland
2
Department of Adult Psychiatry, Poznan University of Medical Sciences, 60-572 Poznań, Poland
3
Department of Psychiatric Nursing, Poznan University of Medical Sciences, 60-179 Poznań, Poland
4
Department of Bioengineering, Faculty of Environmental Management and Agriculture, West Pomeranian University of Technology, 71-434 Szczecin, Poland
5
Chair and Department of Physiology, 70-111 Szczecin, Poland
6
Department of Genetics, Wroclaw Medical University, 50-368 Wrocław, Poland
7
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
8
Department of Regenerative Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(7), 408; https://doi.org/10.3390/brainsci10070408
Submission received: 27 May 2020 / Revised: 27 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Peripheral Biomarkers of Mental Disorders and Related Clinical Features)
Review Reports Versions Notes

Abstract

Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
Keywords: stem cells; VSEL; bipolar disorder stem cells; VSEL; bipolar disorder

Share and Cite

MDPI and ACS Style

Reginia, A.; Samochowiec, J.; Jabłoński, M.; Ferensztajn-Rochowiak, E.; Rybakowski, J.K.; Telesiński, A.; Tarnowski, M.; Misiak, B.; Ratajczak, M.Z.; Kucharska-Mazur, J. Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. Brain Sci. 2020, 10, 408. https://doi.org/10.3390/brainsci10070408

AMA Style

Reginia A, Samochowiec J, Jabłoński M, Ferensztajn-Rochowiak E, Rybakowski JK, Telesiński A, Tarnowski M, Misiak B, Ratajczak MZ, Kucharska-Mazur J. Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. Brain Sciences. 2020; 10(7):408. https://doi.org/10.3390/brainsci10070408

Chicago/Turabian Style

Reginia, Artur, Jerzy Samochowiec, Marcin Jabłoński, Ewa Ferensztajn-Rochowiak, Janusz K. Rybakowski, Arkadiusz Telesiński, Maciej Tarnowski, Błażej Misiak, Mariusz Z. Ratajczak, and Jolanta Kucharska-Mazur. 2020. "Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study" Brain Sciences 10, no. 7: 408. https://doi.org/10.3390/brainsci10070408

APA Style

Reginia, A., Samochowiec, J., Jabłoński, M., Ferensztajn-Rochowiak, E., Rybakowski, J. K., Telesiński, A., Tarnowski, M., Misiak, B., Ratajczak, M. Z., & Kucharska-Mazur, J. (2020). Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. Brain Sciences, 10(7), 408. https://doi.org/10.3390/brainsci10070408

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