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Open AccessArticle

Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients

1
Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu 434-8601, Japan
2
Department of Diagnostic Radiology & Nuclear Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
3
Department of Breast Surgery, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
*
Author to whom correspondence should be addressed.
Both of these authors contributed equally to this work.
Appl. Sci. 2019, 9(7), 1482; https://doi.org/10.3390/app9071482
Received: 31 January 2019 / Revised: 3 April 2019 / Accepted: 4 April 2019 / Published: 9 April 2019
(This article belongs to the Special Issue New Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging)
We previously compared time-domain diffuse optical spectroscopy (TD-DOS) with magnetic resonance imaging (MRI) using various water/lipid phantoms. However, it is difficult to conduct similar comparisons in the breast, because of measurement differences due to modality-dependent differences in posture. Dual-energy computed tomography (DECT) examination is performed in the same supine position as a TD-DOS measurement. Therefore, we first verified the accuracy of the measured fat fraction of fibroglandular tissue in the normal breast on DECT by comparing it with MRI in breast cancer patients (n = 28). Then, we compared lipid and water signals obtained in TD-DOS and DECT from normal and tumor-tissue regions (n = 16). The TD-DOS breast measurements were carried out using reflectance geometry with a source–detector separation of 3 cm. A semicircular region of interest (ROI), with a transverse diameter of 3 cm and a depth of 2 cm that included the breast surface, was set on the DECT image. Although the measurement area differed between the modalities, the correlation coefficients of lipid and water signals between TD-DOS and DECT were rs = 0.58 (p < 0.01) and rs = 0.90 (p < 0.01), respectively. These results indicate that TD-DOS captures the characteristics of the lipid and water contents of the breast. View Full-Text
Keywords: diffuse optical spectroscopy; time-resolved spectroscopy; breast cancer diffuse optical spectroscopy; time-resolved spectroscopy; breast cancer
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Ohmae, E.; Yoshizawa, N.; Yoshimoto, K.; Hayashi, M.; Wada, H.; Mimura, T.; Asano, Y.; Ogura, H.; Yamashita, Y.; Sakahara, H.; Ueda, Y. Comparison of Lipid and Water Contents by Time-domain Diffuse Optical Spectroscopy and Dual-energy Computed Tomography in Breast Cancer Patients. Appl. Sci. 2019, 9, 1482.

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