Next Article in Journal
A Heterogeneous Robotic Swarm for Long-Term Monitoring of Marine Environments
Next Article in Special Issue
Recent Advancement in the Surface-Enhanced Raman Spectroscopy-Based Biosensors for Infectious Disease Diagnosis
Previous Article in Journal
Subway Station Capacity Maintained by Optimizing a Maintenance Schedule of Key Equipment
Previous Article in Special Issue
The Detection of Long-Chain Bio-Markers Using Atomic Force Microscopy
Open AccessArticle

Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor

International Iberian Nanotechnology Laboratory (INL), Avda. Mestre José Veiga, 4715-310 Braga, Portugal
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá (UAH), Crta. Madrid-Barcelona, Km. 33.600, 28805 Alcalá de Henares, Spain
Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisbon, Portugal
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(7), 1387;
Received: 18 February 2019 / Revised: 25 March 2019 / Accepted: 27 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Surfaced Enhanced Raman Scattering (SERS) in Disease Diagnosis)
Surface-enhanced Raman scattering (SERS) spectroscopy stands out due to its sensitivity, selectivity, and multiplex ability. The development of ready-to-use, simple, and low-cost SERS substrates is one of the main challenges of the field. In this paper, the intrinsic reproducibility of microfluidics technology was used for the fabrication of self-assembled nanoparticle structures over a paper film. The paper SERS substrates were fabricated by assembling anisotropic particles, gold nanostars (GNSs), and nanorods (NRs) onto paper to offer an extra enhancement to reach ultra-sensitive detection limits. A polydimethylsiloxane PDMS-paper hybrid device was used to control the drying kinetics of the nanoparticles over the paper substrate. This method allowed a high reproducibility and homogeneity of the fabrication of SERS substrates that reach limits of detection down to the picomolar range. This simple and low-cost fabrication of a paper-based sensing device was tested for the discrimination of different cell lineages. View Full-Text
Keywords: nanotechnology; nanoparticles; self-assembly; microfluidics; SERS; hybrid; nano-biosensors nanotechnology; nanoparticles; self-assembly; microfluidics; SERS; hybrid; nano-biosensors
Show Figures

Graphical abstract

MDPI and ACS Style

Teixeira, A.; Hernández-Rodríguez, J.F.; Wu, L.; Oliveira, K.; Kant, K.; Piairo, P.; Diéguez, L.; Abalde-Cela, S. Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor. Appl. Sci. 2019, 9, 1387.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop