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Open AccessArticle

Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor

1
International Iberian Nanotechnology Laboratory (INL), Avda. Mestre José Veiga, 4715-310 Braga, Portugal
2
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá (UAH), Crta. Madrid-Barcelona, Km. 33.600, 28805 Alcalá de Henares, Spain
3
Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
4
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisbon, Portugal
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(7), 1387; https://doi.org/10.3390/app9071387
Received: 18 February 2019 / Revised: 25 March 2019 / Accepted: 27 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Surfaced Enhanced Raman Scattering (SERS) in Disease Diagnosis)
Surface-enhanced Raman scattering (SERS) spectroscopy stands out due to its sensitivity, selectivity, and multiplex ability. The development of ready-to-use, simple, and low-cost SERS substrates is one of the main challenges of the field. In this paper, the intrinsic reproducibility of microfluidics technology was used for the fabrication of self-assembled nanoparticle structures over a paper film. The paper SERS substrates were fabricated by assembling anisotropic particles, gold nanostars (GNSs), and nanorods (NRs) onto paper to offer an extra enhancement to reach ultra-sensitive detection limits. A polydimethylsiloxane PDMS-paper hybrid device was used to control the drying kinetics of the nanoparticles over the paper substrate. This method allowed a high reproducibility and homogeneity of the fabrication of SERS substrates that reach limits of detection down to the picomolar range. This simple and low-cost fabrication of a paper-based sensing device was tested for the discrimination of different cell lineages. View Full-Text
Keywords: nanotechnology; nanoparticles; self-assembly; microfluidics; SERS; hybrid; nano-biosensors nanotechnology; nanoparticles; self-assembly; microfluidics; SERS; hybrid; nano-biosensors
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MDPI and ACS Style

Teixeira, A.; Hernández-Rodríguez, J.F.; Wu, L.; Oliveira, K.; Kant, K.; Piairo, P.; Diéguez, L.; Abalde-Cela, S. Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor. Appl. Sci. 2019, 9, 1387.

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