Next Article in Journal
A Steam Ejector Refrigeration System Powered by Engine Combustion Waste Heat: Part 1. Characterization of the Internal Flow Structure
Next Article in Special Issue
Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
Previous Article in Journal
Study on Femtosecond Laser Processing Characteristics of Nano-Crystalline CVD Diamond Coating
Previous Article in Special Issue
The Therapeutic Potential of the Labdane Diterpenoid Forskolin

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China
Department of Pharmacology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 7861756447, Iran
Authors to whom correspondence should be addressed.
Appl. Sci. 2019, 9(20), 4270;
Received: 30 August 2019 / Revised: 20 September 2019 / Accepted: 21 September 2019 / Published: 12 October 2019
Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs. View Full-Text
Keywords: piperine; bioactivity; clinical studies; bioavailability of drugs piperine; bioactivity; clinical studies; bioavailability of drugs
MDPI and ACS Style

Stojanović-Radić, Z.; Pejčić, M.; Dimitrijević, M.; Aleksić, A.; V. Anil Kumar, N.; Salehi, B.; C. Cho, W.; Sharifi-Rad, J. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Appl. Sci. 2019, 9, 4270.

AMA Style

Stojanović-Radić Z, Pejčić M, Dimitrijević M, Aleksić A, V. Anil Kumar N, Salehi B, C. Cho W, Sharifi-Rad J. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Applied Sciences. 2019; 9(20):4270.

Chicago/Turabian Style

Stojanović-Radić, Zorica, Milica Pejčić, Marina Dimitrijević, Ana Aleksić, Nanjangud V. Anil Kumar, Bahare Salehi, William C. Cho, and Javad Sharifi-Rad. 2019. "Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies" Applied Sciences 9, no. 20: 4270.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop