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Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

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Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
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Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India
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Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
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Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China
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Department of Pharmacology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 7861756447, Iran
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2019, 9(20), 4270; https://doi.org/10.3390/app9204270
Received: 30 August 2019 / Revised: 20 September 2019 / Accepted: 21 September 2019 / Published: 12 October 2019
Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs. View Full-Text
Keywords: piperine; bioactivity; clinical studies; bioavailability of drugs piperine; bioactivity; clinical studies; bioavailability of drugs
MDPI and ACS Style

Stojanović-Radić, Z.; Pejčić, M.; Dimitrijević, M.; Aleksić, A.; V. Anil Kumar, N.; Salehi, B.; C. Cho, W.; Sharifi-Rad, J. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Appl. Sci. 2019, 9, 4270.

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