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Open AccessArticle

Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect

1
Institute of General Electrical Engineering, University of Rostock, 18051 Rostock, Germany
2
Department of Oral and Maxillofacial Surgery, University Medical Centre Mainz, 55131 Mainz, Germany
3
Department of Orthopaedics, University Medical Center Rostock, 18057 Rostock, Germany
4
Department Life, Light & Matter, University of Rostock, 18051 Rostock, Germany
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(10), 2160; https://doi.org/10.3390/app9102160
Received: 15 April 2019 / Revised: 14 May 2019 / Accepted: 18 May 2019 / Published: 27 May 2019
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering)
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Abstract

Electrical stimulation is a promising therapeutic approach for the regeneration of large bone defects. Innovative electrically stimulating implants for critical size defects in the lower jaw are under development and need to be optimized in silico and tested in vivo prior to application. In this context, numerical modelling and simulation are useful tools in the design process. In this study, a numerical model of an electrically stimulated minipig mandible was established to find optimal stimulation parameters that allow for a maximum area of beneficially stimulated tissue. Finite-element simulations were performed to determine the stimulation impact of the proposed implant design and to optimize the electric field distribution resulting from sinusoidal low-frequency ( f = 20 Hz ) electric stimulation. Optimal stimulation parameters of the electrode length h el = 25 m m and the stimulation potential φ stim = 0.5 V were determined. These parameter sets shall be applied in future in vivo validation studies. Furthermore, our results suggest that changing tissue properties during the course of the healing process might make a feedback-controlled stimulation system necessary. View Full-Text
Keywords: finite-element simulation; electric stimulation; bone regeneration; computational modelling; electrically active implants; bioelectromagnetism; critical size defect; maxillofacial; minipig finite-element simulation; electric stimulation; bone regeneration; computational modelling; electrically active implants; bioelectromagnetism; critical size defect; maxillofacial; minipig
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Raben, H.; Kämmerer, P.W.; Bader, R.; van Rienen, U. Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect. Appl. Sci. 2019, 9, 2160.

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