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Open AccessArticle

Biomechanical Evaluation of the Effect of Mesenchymal Stem Cells on Cartilage Regeneration in Knee Joint Osteoarthritis

Joint Reconstruction Center, Department of Orthopaedic Surgery, Yonsei Sarang Hospital, 10 Hyoryeong-ro, Seocho-gu, Seoul 06698, Korea
Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Department of Sport and Healthy Aging, Korea National Sport University, 1239 Yangjae-dearo, Songpa-gu, Seoul 05541, Korea
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(9), 1868;
Received: 28 March 2019 / Revised: 23 April 2019 / Accepted: 25 April 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering)
Numerous clinical studies have reported cell-based treatments for cartilage regeneration in knee joint osteoarthritis using mesenchymal stem cells (MSCs). However, the post-surgery rehabilitation and weight-bearing times remain unclear. Phenomenological computational models of cartilage regeneration have been only partially successful in predicting experimental results and this may be due to simplistic modeling assumptions and loading conditions of cellular activity. In the present study, we developed a knee joint model of cell and tissue differentiation based on a more mechanistic approach, which was applied to cartilage regeneration in osteoarthritis. First, a phenomenological biphasic poroelastic finite element model was developed and validated according to a previous study. Second, this method was applied to a real knee joint model with a cartilage defect created to simulate the tissue regeneration process. The knee joint model was able to accurately predict several aspects of cartilage regeneration, such as the cell and tissue distributions in the cartilage defect. Additionally, our results indicated that gait cycle loading with flexion was helpful for cartilage regeneration compared to the use of simple weight-bearing loading. View Full-Text
Keywords: stem cell; cartilage; finite element stem cell; cartilage; finite element
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Koh, Y.-G.; Lee, J.-A.; Lee, H.-Y.; Kim, H.-J.; Kang, K.-T. Biomechanical Evaluation of the Effect of Mesenchymal Stem Cells on Cartilage Regeneration in Knee Joint Osteoarthritis. Appl. Sci. 2019, 9, 1868.

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