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Open AccessArticle

Antifungal and Antiaflatoxigenic Activities of 1,8-Cineole and t-Cinnamaldehyde on Aspergillus flavus

1
School of Applied Biosciences, Kyungpook National University, Daegu 41566, Korea
2
Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2018, 8(9), 1655; https://doi.org/10.3390/app8091655
Received: 8 August 2018 / Revised: 2 September 2018 / Accepted: 12 September 2018 / Published: 14 September 2018
Aspergillus flavus and A. parsiticus produce aflatoxins that are highly toxic to mammals and birds. In this study, the inhibitory effects of 1,8-cineole and t-cinnamaldehyde were examined on the growth of Aspergillus flavus ATCC 22546 and aflatoxin production. 1,8-Cineole showed 50% inhibition of fungal growth at a concentration of 250 ppm, while t-cinnamaldehyde almost completely inhibited fungal growth at a concentration of 50 ppm. Furthermore, no fungal growth was observed when the growth medium was treated with 100 ppm t-cinnamaldehyde. 1,8-Cineole also exhibited 50% inhibition on the production of aflatoxin B1 and aflatoxin B2 at a concentration of 100 ppm, while the addition of 100 ppm t-cinnamaldehyde completely inhibited aflatoxin production. These antiaflatoxigenic activities were related to a dramatic downregulation of the expression of aflE and aflL by 1,8-cineole, but the mode of action for t-cinnamaldehyde was unclear. Collectively, our results suggest that both of the compounds are promising alternatives to the currently used disinfectant, propionic acid, for food and feedstuff preservation. View Full-Text
Keywords: aflatoxins; aspergillus flavus; 1,8-cineole; t-cinnamaldehyde; antiaflatoxigenic activity aflatoxins; aspergillus flavus; 1,8-cineole; t-cinnamaldehyde; antiaflatoxigenic activity
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MDPI and ACS Style

Kim, H.-M.; Kwon, H.; Kim, K.; Lee, S.-E. Antifungal and Antiaflatoxigenic Activities of 1,8-Cineole and t-Cinnamaldehyde on Aspergillus flavus. Appl. Sci. 2018, 8, 1655.

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