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Investigation on a Sensitive Chemiluminescence System Based on Ni(IV) Complex to Determine Two β2-Agonist Drugs in Urine and Swine Feed and Their Mechanism

1
Department of Nursing, Xingtai Medical College, Xingtai 054000, China
2
School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang 050017, China
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2018, 8(5), 663; https://doi.org/10.3390/app8050663
Received: 15 March 2018 / Revised: 1 April 2018 / Accepted: 10 April 2018 / Published: 25 April 2018
(This article belongs to the Section Chemistry)
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Abstract

Veterinary drug residues, particularly traces of β2-agonists, can cause various kinds of harmful impact to the environment and public health. Here, a sensitive chemiluminescence (CL) method incorporated with a flow injection analysis is developed for the determination of two β2-agonists [i.e., salbutamol (SAL) and terbutaline (TEB)]. The system is based on the CL reaction of Ni(IV) complex with luminol in alkaline solutions, whereas SAL and TEB can significantly enhance CL intensities. Under optimum conditions, CL intensities are proportional to the SAL and TEB concentration in the range of 1.0 × 10−9 M to 5.0 × 10−7 M and 1.0 × 10−9 M to 1.0 × 10−7 M, respectively. The limits of detection (3σ) are 1.0 × 10−11 M for TEB, and 1.3 × 10−11 for SAL respectively. Relative standard deviations (n = 11) are less than 2% for 5.0 × 10−8 M SAL and TEB. Possible reaction mechanisms for the CL system are suggested based on the CL system spectra, Ni(IV) complex oxidation characteristics, and electron spin resonance (ESR) techniques. The proposed method has been applied to the analysis of urine and swine feed samples with satisfactory results. View Full-Text
Keywords: Ni(IV) complex; β2-agonists; chemiluminescence (CL); determination; mechanism Ni(IV) complex; β2-agonists; chemiluminescence (CL); determination; mechanism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dong, X.; Diao, Y.; Li, X.; Dai, T.; Shi, H.; Li, S. Investigation on a Sensitive Chemiluminescence System Based on Ni(IV) Complex to Determine Two β2-Agonist Drugs in Urine and Swine Feed and Their Mechanism. Appl. Sci. 2018, 8, 663.

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