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Ultrasound-Based Liver Stiffness Surveillance in Patients Treated for Chronic Hepatitis B or C

1
Graduate Institute of Clinical Medical Science, School of Medicine, China Medical University, Taichung 40447, Taiwan
2
School of Medicine, China Medical University, Taichung 40402, Taiwan
3
Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
*
Author to whom correspondence should be addressed.
Appl. Sci. 2018, 8(4), 626; https://doi.org/10.3390/app8040626
Received: 9 March 2018 / Revised: 30 March 2018 / Accepted: 30 March 2018 / Published: 17 April 2018
(This article belongs to the Special Issue Ultrasound Elastography)
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Abstract

Evolving modes of ultrasound-based elastography have achieved promising validity and reliability for evaluating liver fibrosis. Liver stiffness (LS) is a valuable biomarker for modeling liver disease progression and regression on a continuous noncategorical scale as changes in LS per year or for determining the LS progression or regression rate for refining LS measurement (LSM)-based prognostics. The paradigm of LSMs has altered the focus from liver fibrosis staging alone to comprehensive liver-relevant risk estimations. However, diverse ranges of cohort characteristics, disease types, surveillance protocols and timeframes, necroinflammatory resolutions or biochemical responses (BRs), factors explaining the magnitude or kinetics in LS change, virologic responses (VRs), fibrosis reversals (FRs), and noninvasive surveillance results have rarely been reviewed collectively. Elastography-based LS surveillance alone conveys chronological and valuable patient information and assists in characterizing worldwide patient cohorts under antiviral treatment by delineating the concurrent time elapsed, VR, BR, and FR. In groups with uniform VRs to direct-acting antivirals for chronic hepatitis C and nucleoside and nucleotide analogs for chronic hepatitis B, decline in LS can be explained using concurrent BR from 24 weeks to 3 years, followed by FR and the time elapsed. View Full-Text
Keywords: elastography; liver stiffness; chronic hepatitis B; chronic hepatitis C; liver fibrosis; cirrhosis elastography; liver stiffness; chronic hepatitis B; chronic hepatitis C; liver fibrosis; cirrhosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chen, S.-H.; Peng, C.-Y. Ultrasound-Based Liver Stiffness Surveillance in Patients Treated for Chronic Hepatitis B or C. Appl. Sci. 2018, 8, 626.

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