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Applied Sciences
Volume 15
Issue 20
10.3390/app152011027
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion

by
Mariana Gonzalez Utrilla
1,
Bruce Henderson
2,*,
Stuart Kelly
2,
Osian Meredith
2,
Basak Tas
1,
Will Lawn
3,
Elizabeth Appiah-Kusi
1,4,
John F. Dillon
5 and
John Strang
1,4
1
National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London, London SE5 8BB, UK
2
PneumoWave Ltd., Motherwell ML1 4WQ, UK
3
Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AB, UK
4
South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK
5
School of Medicine, University of Dundee, Dundee DD1 4HN, UK
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(20), 11027; https://doi.org/10.3390/app152011027 (registering DOI)
Submission received: 25 July 2025 / Revised: 30 September 2025 / Accepted: 11 October 2025 / Published: 14 October 2025
(This article belongs to the Special Issue Applications of Emerging Biomedical Devices and Systems)
Versions Notes

Abstract

Accidental opioid overdose and Sudden Unexpected Death in Epilepsy (SUDEP) represent major forms of preventable mortality, often involving sudden-onset catastrophic events that could be survivable with rapid detection and intervention. The current physiological monitoring technologies are potentially applicable, but face challenges, including complex setups, poor patient compliance, high costs, and uncertainty about community-based use. Paradoxically, simple clinical observation in supervised injection facilities has proven highly effective, suggesting observable changes in central body motion may be sufficient to detect life-threatening events. We describe a novel wearable biosensor for continuous central body motion monitoring, offering a potential early warning system for life-threatening events. The biosensor incorporates a low-power, triaxial MEMS accelerometer within a discreet, chest-worn device, enabling long-term monitoring with minimal user burden. Two system architectures are described: stored data for retrospective analysis/research, and an in-development system for real-time overdose detection and response. Early user research highlights the importance of accuracy, discretion, and trust for adoption among people who use opioids. The initial clinical data collection, including the OD-SEEN study, demonstrates feasibility for capturing motion data during real-world opioid use. This technology represents a promising advancement in non-invasive monitoring, with potential to improve the outcomes for at-risk populations with multiple health conditions.
Keywords: actigraphy; wearable technology; motion sensors; drug overdose; emergency detection actigraphy; wearable technology; motion sensors; drug overdose; emergency detection

Share and Cite

MDPI and ACS Style

Gonzalez Utrilla, M.; Henderson, B.; Kelly, S.; Meredith, O.; Tas, B.; Lawn, W.; Appiah-Kusi, E.; Dillon, J.F.; Strang, J. Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion. Appl. Sci. 2025, 15, 11027. https://doi.org/10.3390/app152011027

AMA Style

Gonzalez Utrilla M, Henderson B, Kelly S, Meredith O, Tas B, Lawn W, Appiah-Kusi E, Dillon JF, Strang J. Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion. Applied Sciences. 2025; 15(20):11027. https://doi.org/10.3390/app152011027

Chicago/Turabian Style

Gonzalez Utrilla, Mariana, Bruce Henderson, Stuart Kelly, Osian Meredith, Basak Tas, Will Lawn, Elizabeth Appiah-Kusi, John F. Dillon, and John Strang. 2025. "Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion" Applied Sciences 15, no. 20: 11027. https://doi.org/10.3390/app152011027

APA Style

Gonzalez Utrilla, M., Henderson, B., Kelly, S., Meredith, O., Tas, B., Lawn, W., Appiah-Kusi, E., Dillon, J. F., & Strang, J. (2025). Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion. Applied Sciences, 15(20), 11027. https://doi.org/10.3390/app152011027

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