Next Article in Journal
Prediction of Structural Damage Trends Based on the Integration of LSTM and SVR
Next Article in Special Issue
Assessment of Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease
Previous Article in Journal
The Effect of Tool Rotation Speed on the Formation of Eutectic Structure during Friction Stir Welding of Aluminum to Magnesium
Previous Article in Special Issue
Aortic Hemodynamics with Accelerated Dual-Venc 4D Flow MRI in Type B Aortic Dissection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 13
Issue 12
10.3390/app13127134
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

True Non-Contrast Phase versus Virtual-Non Contrast: “Lights and Shadows” of Dual Energy CT Angiography in Peripheral Arterial Disease

by
Chiara Floridi
1,2,3,
Laura Maria Cacioppa
3,
Giacomo Agliata
2,
Michaela Cellina
4,*,
Nicolo’ Rossini
1,
Tommaso Valeri
1,
Martina Curzi
5,
Alessandro Felicioli
3,
Alessandra Bruno
1,
Marzia Rosati
3,
Roberto Candelari
3 and
Andrea Giovagnoni
1,2
1
Department of Clinical, Special and Dental Sciences, University Politecnica delle Marche, 60126 Ancona, Italy
2
Division of Radiology, Department of Radiological Sciences, University Hospital “Azienda Ospedaliera Universitaria delle Marche”, 60126 Ancona, Italy
3
Division of Interventional Radiology, Department of Radiological Sciences, University Hospital “Azienda Ospedaliera Universitaria delle Marche”, 60126 Ancona, Italy
4
Radiology Department, ASST Fatebenefratelli Sacco, 20121 Milan, Italy
5
UOC Radiology, AST Fermo, Marche Region, 63900 Fermo, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2023, 13(12), 7134; https://doi.org/10.3390/app13127134
Submission received: 20 April 2023 / Revised: 10 June 2023 / Accepted: 12 June 2023 / Published: 14 June 2023
(This article belongs to the Special Issue Biomedical Imaging Technologies for Cardiovascular Disease - Volume II)
Browse Figures
Review Reports Versions Notes

Abstract

(1) Background: The value of dual-energy CT angiography (DE-CTA) in the detection of peripheral arterial disease (PAD) has been widely recognized. We aim to evaluate the diagnostic accuracy of virtual non-contrast (VNC) imaging of DE-CTA compared to true non-contrast phase (TNC). (2) Methods: Our Internal Review Board (IRB) approved prospective study enrolled 40 patients (28 men, 12 women; median age 69 y, range 41–93 y) who underwent lower extremity DE-CTA for symptomatic PAD. Mean attenuation values of TNC and VNC were obtained by placing circular regions of interest (ROI) at five levels from the aortic to the popliteal arterial lumen, reported in Hounsfield units (HU), and compared using a two-sample t-test. The subjective quality of VNC images was assessed by two independent radiologists with 10 and 4 years of CTA-imaging experience according to a 4-point scale and verified by the intra-class correlation coefficient (ICC). Dose Length Product (DLP) values of each DE-CTA examination were also considered. (3) Results: Except for the external iliac artery, VNC attenuation values were significantly lower than the corresponding TNC values at all levels, with a mean difference ranging from 14.1 and 8.7 HU. At qualitative analysis, VNC images were considered excellent to diagnose in 40%, good in 50%, and sufficient in 10% of cases. No cases of non-diagnostic VNC imaging were reported. Avoiding the TNC phase, a mean reduction in DLP of 54% for each DE-CTA was estimated. (4) Conclusions: TNC and VNC images showed comparable reliability and diagnostic accuracy in the detection of PAD. VNC may be considered a promising substitute for TNC from the perspectives of dose reduction and workflow optimization.
Keywords: computed tomography angiography; peripheral arterial disease; dual-energy computed tomography; digital scanned projection radiography; dual energy; image reconstructions computed tomography angiography; peripheral arterial disease; dual-energy computed tomography; digital scanned projection radiography; dual energy; image reconstructions

Share and Cite

MDPI and ACS Style

Floridi, C.; Cacioppa, L.M.; Agliata, G.; Cellina, M.; Rossini, N.; Valeri, T.; Curzi, M.; Felicioli, A.; Bruno, A.; Rosati, M.; et al. True Non-Contrast Phase versus Virtual-Non Contrast: “Lights and Shadows” of Dual Energy CT Angiography in Peripheral Arterial Disease. Appl. Sci. 2023, 13, 7134. https://doi.org/10.3390/app13127134

AMA Style

Floridi C, Cacioppa LM, Agliata G, Cellina M, Rossini N, Valeri T, Curzi M, Felicioli A, Bruno A, Rosati M, et al. True Non-Contrast Phase versus Virtual-Non Contrast: “Lights and Shadows” of Dual Energy CT Angiography in Peripheral Arterial Disease. Applied Sciences. 2023; 13(12):7134. https://doi.org/10.3390/app13127134

Chicago/Turabian Style

Floridi, Chiara, Laura Maria Cacioppa, Giacomo Agliata, Michaela Cellina, Nicolo’ Rossini, Tommaso Valeri, Martina Curzi, Alessandro Felicioli, Alessandra Bruno, Marzia Rosati, and et al. 2023. "True Non-Contrast Phase versus Virtual-Non Contrast: “Lights and Shadows” of Dual Energy CT Angiography in Peripheral Arterial Disease" Applied Sciences 13, no. 12: 7134. https://doi.org/10.3390/app13127134

APA Style

Floridi, C., Cacioppa, L. M., Agliata, G., Cellina, M., Rossini, N., Valeri, T., Curzi, M., Felicioli, A., Bruno, A., Rosati, M., Candelari, R., & Giovagnoni, A. (2023). True Non-Contrast Phase versus Virtual-Non Contrast: “Lights and Shadows” of Dual Energy CT Angiography in Peripheral Arterial Disease. Applied Sciences, 13(12), 7134. https://doi.org/10.3390/app13127134

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop