MRI Assessment of the Bi-Leaflet Mechanical Heart Valve: Investigating the EOA Using the Acoustic Source Term Method
, Stuart M. Grieve 5, Jean-François Fontaine 2 and Alain Lalande 6,7Round 1
Reviewer 1 Report
Reviewer’s comments about the submission “MRI Assessment of the Bi-leaflet Mechanical Heart Valve: Investigating the EOA using the Acoustic Source Term Method” as follows
1. Reduce number of abbreviations
2. Provide table number and figure number for to all the figures and tables
3. Provide a bit more information in the captions of tables and figures even these self-explanatory for experts in the given field
4. Method: please mention exactly how many valves were studies
5. Statistics
1. I could not see any box plot, provide
2. I could not see any correlation coefficient , please provide
3. I could not any p value in the result, did the author use it?
4. Did the use Wilcoxon test in this study, I could not see, please mention in the caption of figures or tables where it has been used with additional statistic.
Author Response
Journal: Applied Science
TITLE:
MRI Assessment of the Bi-leaflet Mechanical Heart Valve:
Investigating the EOA using the Acoustic Source Term Method.
NB: applsci-1965787
OBJECTIVES: Responses to Reviewers’ comment
We would like to thank the Editor for giving us the opportunity to revise this manuscript and hope we have addressed all the comments adequately.
Reviewer Comments:
Reviewer 1:
1. Reduce number of abbreviations.
Thanks you for this comment, we indeed reduce the number of abbreviations and left only the necessary ones (suppression of VENC, CFD, PC).
- Provide table number and figure number for to all the figures and tables.
All Table and figure number are now provided ahead to the figure or table and cited in the manuscript.
Provide a bit more information in the captions of tables and figures even these self-explanatory for experts in the given field.
Details of features of each figure and table have been added.
4. Method: please mention exactly how many valves were studies
The list of tested BMHV could be found respectively for experimental data and CFD in Table 1 and Tables 2/3.
Statistics- I could not see any box plot, provide
This is now added in Figure 3.
- I could not see any correlation coefficient, please provide
Considering the design of experiment and the small number of simulations, anova and linear regression was not provided in the article.
- I could not any p value in the result, did the author use it?
p values can now be found in the numerical simulation analysis.
- Did the use Wilcoxon test in this study, I could not see, please mention in the caption of figures or tables where it has been used with additional statistic.
Wilcoxon test results are presented in the numerical simulation analysis.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
M.A. Evin et alt. provided an experimental model to test the possible usefulness of the EOA calculated by AST in the context of Bi-leaflet Mechanical Heart Valve.
The model is strictly reported and the work is well-written and intriguing for its possible applications in clinical practice.
I've got only two minor considerations
- the abstract is even too concise, I suggest rewriting it considering the articulation in background, methods, results, conclusions.
- The period " when translated to MRI... detect vena contracta" appeared more as part of the Methods rather than background
Best Regards
Author Response
Journal: Applied Science
TITLE:
MRI Assessment of the Bi-leaflet Mechanical Heart Valve:
Investigating the EOA using the Acoustic Source Term Method.
NB: applsci-1965787
OBJECTIVES: Responses to Reviewers’ comment
We would like to thank the Editor for giving us the opportunity to revise this manuscript and hope we have addressed all the comments adequately.
Reviewer Comments:
Reviewer 2:
The model is strictly reported and the work is well-written and intriguing for its possible applications in clinical practice.
I've got only two minor considerations
We thank the reviewer for the comments.
- the abstract is even too concise, I suggest rewriting it considering the articulation in background, methods, results, conclusions.
The abstract has been extended accordingly.
- The period " when translated to MRI... detect vena contracta" appeared more as part of the Methods rather than background.
This part has been moved to the Methods section.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Only one type of valve could have been used and sample size could have been more to provide a more clear direction for future research in this direction
