Limonin Derivatives via Hydrogenation: Structural Identification and Anti-Inflammatory Activity Evaluation
Round 1
Reviewer 1 Report
In this paper, the authors investigated the hydrogenation of limonin with a variety of reducing agents. The resulting compounds are expected, however, they reported six newly synthesized molecules, and did the evaluation of the biological activity of natural and reduced derivatives.
The whole paper, especially the introduction, methodology, and conclusion is extremely well, clearly, and precisely written. The obtained results are not so significant but they are in agreement with the set goals and hypotheses. Maybe some of the spectral data could be moved from the results to supplementary data.
Author Response
We thank the reviewer for pointing out this issue. As suggested by the reviewer, some spectral data discussed in the results have been removed.
Reviewer 2 Report
As a result of the examination of the article sent to Applied Sciences for publication, the following corrections should be made.
1- Especially NMR spectra of new compounds should be given to the supplementary materials section.
2- The literature on known compounds should be given in the relevant section.
3- References should be reviewed. For example 3rd and 18th same article.
Author Response
1.Especially NMR spectra of new compounds should be given to the supplementary materials section.
Response:
We thank the reviewer for the suggestion. Actually, as the reviewer mentioned, the NMR spectra of new compounds were given in the supplementary data. To make this point clearer, the corresponding figure number has been added in the manuscript.
2.The literature on known compounds should be given in the relevant section.
Response:
We thank the reviewer for pointing out this issue. As suggested, the literature on known compounds was added.
3.References should be reviewed. For example 3rd and 18th same article.1.
Response:
We thank the reviewer for pointing out this issue. The references have been checked and edited.
