Next Article in Journal
Bone Damage during Dental Implant Insertion: A Pilot Study Combining Strain Gauge and Histologic Analysis
Previous Article in Journal
Numerical Simulation of Rockfill Materials Based on Fractal Theory
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 12
Issue 1
10.3390/app12010290
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells

by
Soo-Jeung Park
1,2,
Minhee Lee
3,
Ki-Young Kim
4,
Su Shin
4,
Min-Woo Choi
4,
Eun-Jin Hong
4 and
Jeongmin Lee
2,3,*
1
Beirne B. Cater Center for Immunology Research, University of Virginia, Charlottesville, VA 22901, USA
2
Clinical Nutrition Institute, Kyung Hee University, Seoul 02453, Korea
3
Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea
4
Research Institute, Bio Port Korea Inc., Busan 46048, Korea
*
Author to whom correspondence should be addressed.
Appl. Sci. 2022, 12(1), 290; https://doi.org/10.3390/app12010290
Submission received: 26 October 2021 / Revised: 20 December 2021 / Accepted: 27 December 2021 / Published: 29 December 2021
(This article belongs to the Topic Applied Sciences in Functional Foods)
Browse Figures
Versions Notes

Abstract

Our study investigated that the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. To this end, 3T3-L1 cells were treated with TJ during their differentiation period. On the last day of the cell culture, we tested intracellular cAMP, FA, glycerol release, TG, and performed Oil Red O staining and Western blot assays. On the part of adipogenesis, lipogenesis, and lipolysis mechanism, TJ increased the cAMP (maximum 125.4%) levels and glycerol release (maximum four times) and decreased FA (maximum 35.1%) and TG (maximum 35.7%) levels. Furthermore, the protein expression levels of each mechanism-related factor were regulated in a dose-dependent manner. These results indicate that TJ reduced lipid accumulation by max 53.6% and 47.9%, respectively, in adipogenesis and lipolysis mechanisms. We expect this effect of TJ to be due to its component, ellagic acid. In conclusion, we found that TJ inhibits TG synthesis during adipogenesis and lipogenesis, promotes lipolysis, and thus, indicating its potential as a functional food for obesity prevention.
Keywords: Trapa japonica Flerov; adipogenesis; lipogenesis; lipolysis; 3T3-L1; anti-obesity Trapa japonica Flerov; adipogenesis; lipogenesis; lipolysis; 3T3-L1; anti-obesity

Share and Cite

MDPI and ACS Style

Park, S.-J.; Lee, M.; Kim, K.-Y.; Shin, S.; Choi, M.-W.; Hong, E.-J.; Lee, J. Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells. Appl. Sci. 2022, 12, 290. https://doi.org/10.3390/app12010290

AMA Style

Park S-J, Lee M, Kim K-Y, Shin S, Choi M-W, Hong E-J, Lee J. Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells. Applied Sciences. 2022; 12(1):290. https://doi.org/10.3390/app12010290

Chicago/Turabian Style

Park, Soo-Jeung, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, and Jeongmin Lee. 2022. "Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells" Applied Sciences 12, no. 1: 290. https://doi.org/10.3390/app12010290

APA Style

Park, S.-J., Lee, M., Kim, K.-Y., Shin, S., Choi, M.-W., Hong, E.-J., & Lee, J. (2022). Trapa japonica Flerov Extract Prevents Obesity by Regulating Adipogenesis and Lipolysis in Differentiated 3T3-L1 Cells. Applied Sciences, 12(1), 290. https://doi.org/10.3390/app12010290

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop