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Article

Laser Induced Method to Produce Curcuminoid-Silanol Thin Films for Transdermal Patches Using Irradiation of Turmeric Target

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Faculty of Physics, Atmosphere Optics, Spectroscopy and Laser Laboratory (LOASL), Alexandru Ioan Cuza University of Iasi, 11 Carol I Boulevard, 700506 Iasi, Romania
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Faculty of Material Science and Engineering, Gheorghe Asachi Technical University of Iasi, 59A Mangeron Boulevard, 700050 Iasi, Romania
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Rehabilitation Hospital Borsa, 1 Floare de Colt street, 435200 Borsa, Romania
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Department of Chemical Engineering in Textiles and Leather, Gheorghe Asachi Technical University of Iasi, 29 Boulevard Dimitrie Mangeron, 700050 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrea Li Bassi
Appl. Sci. 2021, 11(9), 4030; https://doi.org/10.3390/app11094030
Received: 29 March 2021 / Revised: 23 April 2021 / Accepted: 25 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue Active Materials for Medical Applications)
A new possible method to produce a transdermal patch is proposed in this paper. The study refers to the pulsed laser deposition method (PLD) applied on turmeric target in order to obtain thin layers. Under high power laser irradiation of 532 nm wavelength, thin films containing curcuminoids were obtained on different substrates such as glass and quartz (laboratory investigation) and hemp fabric (practical application). Compared FTIR, SEM-EDS and LIF analyses proved that the obtained thin film chemical composition is mainly demethoxycurcumin and bisdemethoxycurcumin which is evidence that most of the curcumin from turmeric has been demethixylated during laser ablation. Silanol groups with known role into dermal reconstruction are evidenced in both turmeric target and curcuminoid thin films. UV–VIS reflection spectra show the same characteristics for all the curcuminoid thin films, indicating that the method is reproducible. The method proves to be successful for producing a composite material, namely curcuminoid transdermal patch with silanol groups, using directly turmeric as target in the thin film deposited by pulsed laser technique. Double layered patch curcuminoid—silver was produced under this study, proving compatibility between the two deposited layers. The silver layer added on curcuminoid-silanol layer aimed to increase antiseptic properties to the transdermal patch. View Full-Text
Keywords: PLD; turmeric; curcuminoid-silanol films; transdermal patch; demetoxilation; SEM-EDS; LIF; hemp composite PLD; turmeric; curcuminoid-silanol films; transdermal patch; demetoxilation; SEM-EDS; LIF; hemp composite
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MDPI and ACS Style

Cocean, A.; Cocean, I.; Cimpoesu, N.; Cocean, G.; Cimpoesu, R.; Postolachi, C.; Popescu, V.; Gurlui, S. Laser Induced Method to Produce Curcuminoid-Silanol Thin Films for Transdermal Patches Using Irradiation of Turmeric Target. Appl. Sci. 2021, 11, 4030. https://doi.org/10.3390/app11094030

AMA Style

Cocean A, Cocean I, Cimpoesu N, Cocean G, Cimpoesu R, Postolachi C, Popescu V, Gurlui S. Laser Induced Method to Produce Curcuminoid-Silanol Thin Films for Transdermal Patches Using Irradiation of Turmeric Target. Applied Sciences. 2021; 11(9):4030. https://doi.org/10.3390/app11094030

Chicago/Turabian Style

Cocean, Alexandru, Iuliana Cocean, Nicanor Cimpoesu, Georgiana Cocean, Ramona Cimpoesu, Cristina Postolachi, Vasilica Popescu, and Silviu Gurlui. 2021. "Laser Induced Method to Produce Curcuminoid-Silanol Thin Films for Transdermal Patches Using Irradiation of Turmeric Target" Applied Sciences 11, no. 9: 4030. https://doi.org/10.3390/app11094030

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