Focal Vibration Therapy: Vibration Parameters of Effective Wearable Devices
Round 1
Reviewer 1 Report
There are some weaknesses through the manuscript which need improvement. Therefore, the submitted manuscript cannot be accepted for publication in this form, but it has a chance of acceptance after a major revision. My comments and suggestions are as follows:
1- Abstract gives information on the main feature of the performed study, but some details about the utilized focal vibration devices must be added.
2- Authors must clarify necessity of the performed research. Aims and objectives of the study must be clearly mentioned in the last part of introduction. The claim like “this is the first work that rigorously evaluates current …” must be avoided.
3- The literature study must be enriched. In this respect, authors must read and refer to the following papers: (a) https://doi.org/10.1016/j.sna.2020.112105 (b) https://doi.org/10.1016/j.micpro.2020.103687
4- In all formula, typing in italic style must be avoided. Text in formula must be normal (not italic).
5- The main reference of each formula must be cited. Moreover, each parameters in equations must be introduced. Please double check this issue.
6- It would be nice, if authors could prepare curves in MATLAB environment.
7- In its language layer, the manuscript should be considered for English language editing. There are sentences which have to be rewritten.
8- The conclusion must be more than just a summary of the manuscript. List of references must be updated based on the proposed papers. Please provide all changes by red color in the revised version.
Author Response
There are some weaknesses through the manuscript which need improvement. Therefore, the submitted manuscript cannot be accepted for publication in this form, but it has a chance of acceptance after a major revision. My comments and suggestions are as follows:
1- Abstract gives information on the main feature of the performed study, but some details about the utilized focal vibration devices must be added.
Thank you for the suggestions and we added the details of the tested devices and edited the abstract as suggested.
2- Authors must clarify necessity of the performed research. Aims and objectives of the study must be clearly mentioned in the last part of introduction. The claim like “this is the first work that rigorously evaluates current …” must be avoided.
Thank you for the comments. We added more justifications on the needs of the assessing the vibration parameters and edited the introduction as suggested. Aims and objectives of the study were added as well.
3- The literature study must be enriched. In this respect, authors must read and refer to the following papers: (a) https://doi.org/10.1016/j.sna.2020.112105 (b) https://doi.org/10.1016/j.micpro.2020.103687
Thank you for your recommendation. We enriched our literature to support the need of the study, as well as neurophysiological responses to focal vibration. The two papers you suggested here are very interesting and actually critical for our next step to improve current wearable focal vibration technology. We were conducting some patient study on the effectiveness of wearable focal vibration and one notable limitation of current wearable focal vibration technology is the fabrication and the attachment.
4- In all formula, typing in italic style must be avoided. Text in formula must be normal (not italic).
Thank you for the comments and the suggested changes had been made.
5- The main reference of each formula must be cited. Moreover, each parameters in equations must be introduced. Please double check this issue.
Thank you. We addressed your comments.
6- It would be nice, if authors could prepare curves in MATLAB environment.
Thank you. We changed the curves in MATLAB environment.
7- In its language layer, the manuscript should be considered for English language editing. There are sentences which have to be rewritten.
Thank you. We asked an English Editor proof-read the revision and edited the paper as necessary.
8- The conclusion must be more than just a summary of the manuscript. List of references must be updated based on the proposed papers. Please provide all changes by red color in the revised version.
Thank you and we edited the conclusion and revised the references as suggested.
Reviewer 2 Report
Review of the article "Focal Vibration Therapy: Vibration Parameters of Effective 2 Wearable Devices". An interesting and necessary work is presented. It was very interesting for me to read it. In my opinion, the manuscript fully meets the requirements for scientific publications, despite the significant narrowly applied significance of the manuscript. Despite the overall positive assessment, there are two questions that autos need not only to answer, but also to significantly supplement the text of the manuscript.
1. Most experts do not consider vibration therapy as an effective type of therapy, due to the lack of knowledge of the mechanisms of action of vibration therapy on biological objects. This publication contains the same error. And I think this error needs to be corrected! It is necessary to add a paragraph to the introduction in which the basic mechanisms underlying the effective use of vibration therapy will be considered. For example, at the macro (tissue or organ) level, vibration therapy works by improving the supply of blood to the tissue. This is, on the one hand, the effect of compression and stretching of muscles or bones, and on the other hand, "resonant hemodynamics" (https://doi.org/10.1186/s11556-020-00247-5). At the molecular level, vibrations lead to the formation of hydrogen peroxide in water and biological fluids (https://doi.org/10.3390/ijms21218033). It is known that hydrogen peroxide is an important signal-regulatory molecule involved in the regulation of many processes (https://doi.org/10.1016/j.mito.2020.01.002). In general, for non-specialists, the authors need to write an understandable introduction, to build vibration therapy into the tree of modern science.
2. I would like to see in the article a more detailed explanation of why the authors use frequencies that are multiples of 60.
Author Response
Review of the article "Focal Vibration Therapy: Vibration Parameters of Effective 2 Wearable Devices". An interesting and necessary work is presented. It was very interesting for me to read it. In my opinion, the manuscript fully meets the requirements for scientific publications, despite the significant narrowly applied significance of the manuscript. Despite the overall positive assessment, there are two questions that autos need not only to answer, but also to significantly supplement the text of the manuscript.
1. Most experts do not consider vibration therapy as an effective type of therapy, due to the lack of knowledge of the mechanisms of action of vibration therapy on biological objects. This publication contains the same error. And I think this error needs to be corrected! It is necessary to add a paragraph to the introduction in which the basic mechanisms underlying the effective use of vibration therapy will be considered. For example, at the macro (tissue or organ) level, vibration therapy works by improving the supply of blood to the tissue. This is, on the one hand, the effect of compression and stretching of muscles or bones, and on the other hand, "resonant hemodynamics" (https://doi.org/10.1186/s11556-020-00247-5). At the molecular level, vibrations lead to the formation of hydrogen peroxide in water and biological fluids (https://doi.org/10.3390/ijms21218033). It is known that hydrogen peroxide is an important signal-regulatory molecule involved in the regulation of many processes (https://doi.org/10.1016/j.mito.2020.01.002). In general, for non-specialists, the authors need to write an understandable introduction, to build vibration therapy into the tree of modern science.
Thank you very much for your detailed comments and recommendations on the articles to be included to support the usage of focal vibration, especially the potential mechanism. Those will not only benefit this manuscript but also help us to explain the clinical findings and guide our future work. We appreciated your suggestions and made the changes. We also added how focal vibration stimulates both peripheral and neuromuscular system.
2. I would like to see in the article a more detailed explanation of why the authors use frequencies that are multiples of 60.
Thank you for pointing this out. We originally picked the frequencies that are multiples of 60 just as a quick example, and 60 was picked because the most frequently used frequencies in the clinical literatures are 60HZ and 120Hz. We changed this figure to a 3D plot in our revision.
Round 2
Reviewer 1 Report
The paper has been improved and corresponding modifications have been conducted. In my opinion, the current version can be considered for publication.
Reviewer 2 Report
Done
