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Hypothesis

Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

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SET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy
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Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
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Foundation of Physics Research Center, 87100 Cosenza, Italy
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Director of Multidisciplinary Research Center, Lincoln University, Oakland, CA 94612, USA
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Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, Campus Universitario “E. Quagliariello”, 70125 Bari, Italy
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Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
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American Stem Cells Hospital and Human Stem Cells Institute, Ho Chi Minh City 70000, Vietnam
*
Author to whom correspondence should be addressed.
Academic Editor: Natália Martins
Appl. Sci. 2021, 11(4), 1696; https://doi.org/10.3390/app11041696
Received: 27 January 2021 / Revised: 5 February 2021 / Accepted: 10 February 2021 / Published: 14 February 2021
(This article belongs to the Special Issue New Trends in Biosciences)
Due to the promising effects of mesenchymal stem cells (MSCs) in the treatment of various diseases, this commentary aimed to focus on the auxiliary role of MSCs to reduce inflammatory processes of acute respiratory infections caused by the 2019 novel coronavirus (COVID-19). Since early in 2020, COVID-19, a consequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly affected millions of people world-wide. The SARS-CoV-2 infection in children appears to be an unusual event. Despite the high number of affected adult and elderly, children and adolescents remained low in amounts, and marginally touched. Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying MSCs cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-2; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); immune system COVID-19; SARS-CoV-2; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); immune system
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MDPI and ACS Style

Balzanelli, M.G.; Distratis, P.; Catucci, O.; Cefalo, A.; Lazzaro, R.; Inchingolo, F.; Tomassone, D.; Aityan, S.K.; Ballini, A.; Nguyen, K.C.D.; Gargiulo Isacco, C. Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection. Appl. Sci. 2021, 11, 1696. https://doi.org/10.3390/app11041696

AMA Style

Balzanelli MG, Distratis P, Catucci O, Cefalo A, Lazzaro R, Inchingolo F, Tomassone D, Aityan SK, Ballini A, Nguyen KCD, Gargiulo Isacco C. Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection. Applied Sciences. 2021; 11(4):1696. https://doi.org/10.3390/app11041696

Chicago/Turabian Style

Balzanelli, Mario G., Pietro Distratis, Orazio Catucci, Angelo Cefalo, Rita Lazzaro, Francesco Inchingolo, Diego Tomassone, Sergey K. Aityan, Andrea Ballini, Kieu C.D. Nguyen, and Ciro Gargiulo Isacco. 2021. "Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection" Applied Sciences 11, no. 4: 1696. https://doi.org/10.3390/app11041696

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