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Article

Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys

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Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania
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Technical Sciences Academy of Romania, 26 Dacia Blvd., 030167 Bucharest, Romania
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Faculty of Material Science and Engineering Department, Gheorghe Asachi University of Iasi, 41 Dimitrie Mangeron Str., 700050 Iasi, Romania
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Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy from Iasi, 9-13 Kogălniceanu Str., 700454 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2021, 11(3), 981; https://doi.org/10.3390/app11030981
Received: 22 December 2020 / Revised: 9 January 2021 / Accepted: 15 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Active Materials for Medical Applications)
The subject of Mg-based biodegradable materials, used for medical applications, has been extensively studied throughout the years. It is a known fact that alloying Mg with biocompatible and non-toxic elements improves the biodegradability of the alloys that are being used in the field of surgical applications. The aim of this research is to investigate the aspects concerning the microstructure, electrochemical response (corrosion resistance) and in vitro cytocompatibility of a new experimental Mg-based biodegradable alloy—Mg–0.5%Ca with controlled addition of Gd as follows: 0.5, 1.0, 1.5, 2.0 and 3.0 wt.%—in order to establish improved biocompatibility with the human hard and soft tissues at a stable biodegradable rate. For this purpose, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM) and X-ray diffraction (XRD) were used for determining the microstructure and chemical composition of the studied alloy and the linear polarization resistance (LPR) method was used to calculate the corrosion rate for the biodegradability rate assessment. The cellular response was evaluated using the 3-(4,5-dimethyltiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test followed by fluorescence microscopy observation. The research led to the discovery of a dendritic α-Mg solid solution, as well as a lamellar Mg2Ca and a Mg5Gd intermetallic compound. The in vivo tests revealed 73–80% viability of the cells registered at 3 days and between 77 and 100% for 5 days, a fact that leads us to believe that the experimental studied alloys do not have a cytotoxic character and are suitable for medical applications. View Full-Text
Keywords: Mg–Ca–Gd alloys; SEM; EDS; microstructure; electrochemical evaluation; in vitro test Mg–Ca–Gd alloys; SEM; EDS; microstructure; electrochemical evaluation; in vitro test
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MDPI and ACS Style

Istrate, B.; Munteanu, C.; Cimpoesu, R.; Cimpoesu, N.; Popescu, O.D.; Vlad, M.D. Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys. Appl. Sci. 2021, 11, 981. https://doi.org/10.3390/app11030981

AMA Style

Istrate B, Munteanu C, Cimpoesu R, Cimpoesu N, Popescu OD, Vlad MD. Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys. Applied Sciences. 2021; 11(3):981. https://doi.org/10.3390/app11030981

Chicago/Turabian Style

Istrate, Bogdan, Corneliu Munteanu, Ramona Cimpoesu, Nicanor Cimpoesu, Oana D. Popescu, and Maria D. Vlad 2021. "Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys" Applied Sciences 11, no. 3: 981. https://doi.org/10.3390/app11030981

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