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Article

Fat Graft in Surgical Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)

1
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80138 Naples, Italy
2
Department of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
3
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel X.B. Chen
Appl. Sci. 2021, 11(23), 11195; https://doi.org/10.3390/app112311195 (registering DOI)
Received: 11 October 2021 / Revised: 17 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
Background: Although the published literature has grown exponentially during the last few decades, managing medication-related osteonecrosis of the jaws (MRONJ) remains challenging. Since the first description of adipose-derived stem cells, cell therapy showed promising perspectives in surgical treatment of MRONJ. In this study, the beneficial effect of fat graft in surgical treatment of stage 2 and 3 MRONJ patients was assessed. Methods: A retrospective analysis of the evolution pattern of the disease was conducted comparing the outcomes of MRONJ patients who underwent sequestrectomy followed by fat graft (n = 9) and those who received sequestrectomy alone (n = 12). Results: Improvement of the disease stage was observed in 77.8% vs. 22.2% cases in group A and B, respectively (p = 0.030); disease stability was documented in 11.1% vs. 25.0% cases in group A and B, respectively (p = 0.603); worsening of MRONJ stage was observed in 11.1% vs. 50.0% cases in group A and B, respectively (p = 0.159). Conclusions: Despite the small sample size, this study suggests that fat graft may represent a promising low-risk and cost-efficient adjunctive therapy in the surgical treatment of MRONJ patients. View Full-Text
Keywords: medication-related osteonecrosis of the jaws; MRONJ; BRONJ; fat graft; adipose tissue graft; adipose-derived stem cells; adipose-derived stromal cells; ASC; ASCs; mesenchymal stem cells medication-related osteonecrosis of the jaws; MRONJ; BRONJ; fat graft; adipose tissue graft; adipose-derived stem cells; adipose-derived stromal cells; ASC; ASCs; mesenchymal stem cells
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MDPI and ACS Style

De Cicco, D.; Tartaro, G.; Colella, G.; Dell’Aversana Orabona, G.; Santagata, M.; Ferrieri, I.; Troiano, A.; Staglianò, S.; Volgare, A.S.; D’Amato, S. Fat Graft in Surgical Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ). Appl. Sci. 2021, 11, 11195. https://doi.org/10.3390/app112311195

AMA Style

De Cicco D, Tartaro G, Colella G, Dell’Aversana Orabona G, Santagata M, Ferrieri I, Troiano A, Staglianò S, Volgare AS, D’Amato S. Fat Graft in Surgical Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ). Applied Sciences. 2021; 11(23):11195. https://doi.org/10.3390/app112311195

Chicago/Turabian Style

De Cicco, Davide, Gianpaolo Tartaro, Giuseppe Colella, Giovanni Dell’Aversana Orabona, Mario Santagata, Ivo Ferrieri, Antonio Troiano, Samuel Staglianò, Andrea S. Volgare, and Salvatore D’Amato. 2021. "Fat Graft in Surgical Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ)" Applied Sciences 11, no. 23: 11195. https://doi.org/10.3390/app112311195

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