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Article

The Role of Nutritional Habits and Moderate Red Wine Consumption in PON1 Status in Healthy Population

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Laboratorio de Contaminación y Toxicología, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Tepic 63000, Mexico
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Posgrado en Ciencias Biológico Agropecuarias, Universidad Autónoma de Nayarit, Xalisco 63794, Mexico
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Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Tepic 63000, Mexico
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Centro Nayarita de Innovación y Transferencia de Tecnología “Unidad especializada en I+D+i en Calidad de Alimentos y Productos Naturales”, Universidad Autónoma de Nayarit, Tepic 63000, Mexico
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Postdoctoral Research Fellow-CONACyT-Mx, Laboratory of Precision Environmental Health, Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Teresa Leszczyńska, Joanna Kapusta-Duch and Ewa Piątkowska
Appl. Sci. 2021, 11(20), 9503; https://doi.org/10.3390/app11209503
Received: 24 September 2021 / Revised: 1 October 2021 / Accepted: 9 October 2021 / Published: 13 October 2021
Paraoxonase 1 (PON1) plays a role as antioxidant on HDL. Including in diet additionally ingest of polyphenolic compounds can stimulate PON1 transcription and increase its activity. The aim of this study was to evaluate the effect of dietary intake, red wine consumption, and PON1 genotypes (Q192R, L55M and C-108T) on the specific activity of PON1 in a healthy population. A descriptive and analytical pilot study was conducted in Mexican volunteers clinically healthy (n = 45) aged from 21–59 years. Over 6 weeks, the study participants ingested 120 mL of red wine per day. PON1 concentration, PON1 activities, genetic polymorphisms and dietary intake were evaluated. The preliminary fingerprinting of the wine was determined to corroborate the presence of phenolic compounds such as tannins and gallotannins. Neither dietary intake nor PON1 genotypes showed an effect on the specific activity of PON1. However, a significant increase in specific AREase activity after red wine consumption period was observed in the study participants. Our data suggest that the moderate consumption of red wine has a beneficial effect on PON1 specific AREase activity in this healthy Mexican population. View Full-Text
Keywords: PON1; red wine; PON1 genotypes; AREase activity; phenolic compounds; UPLC-MS PON1; red wine; PON1 genotypes; AREase activity; phenolic compounds; UPLC-MS
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MDPI and ACS Style

Navarro-García, F.; Ponce-Ruíz, N.; Rojas-García, A.E.; Ávila-Villarreal, G.; Herrera-Moreno, J.F.; Barrón-Vivanco, B.S.; Bernal-Hernández, Y.Y.; González-Arias, C.A.; Medina-Díaz, I.M. The Role of Nutritional Habits and Moderate Red Wine Consumption in PON1 Status in Healthy Population. Appl. Sci. 2021, 11, 9503. https://doi.org/10.3390/app11209503

AMA Style

Navarro-García F, Ponce-Ruíz N, Rojas-García AE, Ávila-Villarreal G, Herrera-Moreno JF, Barrón-Vivanco BS, Bernal-Hernández YY, González-Arias CA, Medina-Díaz IM. The Role of Nutritional Habits and Moderate Red Wine Consumption in PON1 Status in Healthy Population. Applied Sciences. 2021; 11(20):9503. https://doi.org/10.3390/app11209503

Chicago/Turabian Style

Navarro-García, Fidel, Néstor Ponce-Ruíz, Aurora E. Rojas-García, Gabriela Ávila-Villarreal, José F. Herrera-Moreno, Briscia S. Barrón-Vivanco, Yael Y. Bernal-Hernández, Cyndia A. González-Arias, and Irma M. Medina-Díaz 2021. "The Role of Nutritional Habits and Moderate Red Wine Consumption in PON1 Status in Healthy Population" Applied Sciences 11, no. 20: 9503. https://doi.org/10.3390/app11209503

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