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Neurotrophic Factors in Glaucoma and Innovative Delivery Systems
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Review

In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review

Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, University of Pisa, 56126 Pisa, Italy
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Authors to whom correspondence should be addressed.
Appl. Sci. 2021, 11(2), 724; https://doi.org/10.3390/app11020724
Received: 12 December 2020 / Revised: 6 January 2021 / Accepted: 12 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Glaucoma: Innovative Drug Delivery Systems for Its Treatment)
Adherence is crucial in medical glaucoma therapy, although half of the patients skip eyedrops. In recent years alternative drug-delivery systems have been developed. One of the most promising seems the contact lens (CL). This systematic review aims to present the in vivo efficacy of different CL drug-delivery systems. A total of 126 studies were identified following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. After full-text evaluation, 19 studies about CL drug-delivery systems were included. To date, the following drug-delivery systems have been investigated in vivo: drug-soaked CL, CL with physical barriers (vitamin E), molecularly imprinted CL, CL with implants, and nanoparticle-loaded CL. Nanoparticle-loaded CL and CL with implants seem the most promising drug-delivery systems, although initial burst drug release and patient acceptance may limit their widespread use in current practice. Clinical trials are warranted to understand the role of CL as a drug-delivery system in improving glaucomatous patient care. View Full-Text
Keywords: contact lens; drug-delivery system; glaucoma; nanoparticles; adherence contact lens; drug-delivery system; glaucoma; nanoparticles; adherence
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MDPI and ACS Style

Sartini, F.; Menchini, M.; Posarelli, C.; Casini, G.; Figus, M. In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review. Appl. Sci. 2021, 11, 724. https://doi.org/10.3390/app11020724

AMA Style

Sartini F, Menchini M, Posarelli C, Casini G, Figus M. In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review. Applied Sciences. 2021; 11(2):724. https://doi.org/10.3390/app11020724

Chicago/Turabian Style

Sartini, Francesco, Martina Menchini, Chiara Posarelli, Giamberto Casini, and Michele Figus. 2021. "In Vivo Efficacy of Contact Lens Drug-Delivery Systems in Glaucoma Management. A Systematic Review" Applied Sciences 11, no. 2: 724. https://doi.org/10.3390/app11020724

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