Limbic Encephalitis with HU-Antibodies in T-cell Anaplastic Lymphoma. A Case Report

Round 1

Reviewer 1 Report

The Authors reported on an interesting and rare case of limbic encephalitis associated with HU antibodies, in a patient with T cell anaplastic lymphoma. The case is well-written and well presented.

Author Response

Dear Editor,

Thank you for your letter of Jun 2021 informing us that our manuscript number has been found to be of interest by Applied Sciences, pending the solving of some criticisms arisen by the reviewers.

We modified the paper according to your and reviewers’ suggestions. Enclosed please find the revised manuscript with changes highlighted. The list of changes made in response to the specific reviewers’ comments is specified below

REVIEWER #1

Q1. The Authors reported on an interesting and rare case of limbic encephalitis associated with HU antibodies, in a patient with T cell anaplastic lymphoma. The case is well-written and well presented.

A1. Thank you.

Reviewer 2 Report

Here are comments for the study.

" The Authors demonstrated a rare case of limbic encephalitis related to HU-antibodies in a patient with T cell anaplastic lymphoma. Overall manuscript is well written, however there are parts that should be revised before publication.

1. Please make a table for the patients' medical condition including white blood cells count, lactate, LDH, etc.

2. All the abbreviations used should be explained at their first appearances. For example, HU, ALK, MRI and so forth.

Author Response

Dear Editor,

Thank you for your letter of Jun 2021 informing us that our manuscript number has been found to be of interest by Applied Sciences, pending the solving of some criticisms arisen by the reviewers.

We modified the paper according to your and reviewers’ suggestions. Enclosed please find the revised manuscript with changes highlighted. The list of changes made in response to the specific reviewers’ comments is specified below

REVIEWER #2

Q1. Please make a table for the patients' medical condition including white blood cells count, lactate, LDH, etc.

R1. According to reviewer’s observation, we have added a table of patients’ main laboratory data.

Q2. All the abbreviations used should be explained at their first appearances. For example, HU, ALK, MRI and so forth.

A2. Abbreviations and acronyms have been explained.

Reviewer 3 Report

The authors report a rare case of paraneoplastic limbic encephalitis associated with HU antibodies in a patient and find this patient with anaplastic T cell lymphoma completely respond to the hematological therapy.

I suggest authors show the results of anti-Hu antibody examination for autoantibody screening, and the paper can be interesting for the readers and in this form can be published in Applied Sciences.

Author Response

Dear Editor,

Thank you for your letter of Jun 2021 informing us that our manuscript number has been found to be of interest by Applied Sciences, pending the solving of some criticisms arisen by the reviewers.

We modified the paper according to your and reviewers’ suggestions. Enclosed please find the revised manuscript with changes highlighted. The list of changes made in response to the specific reviewers’ comments is specified below.

REVIEWER #3

Q1. I suggest authors show the results of anti-Hu antibody examination for autoantibody screening, and the paper can be interesting for the readers and in this form can be published in Applied Sciences.

A1 Following the reviewer’s suggestion the autoantibody screening panel and its results have been reported in Table 1.

Round 2

Reviewer 2 Report

Authors revised the manuscript according the suggestion.